prikaz prve stranice dokumenta Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials
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Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials
Journal of Clinical Lipidology, 12 (2018), 3; 801-809. https://doi.org/10.1016/j.jacl.2018.01.008
Sahebkar, Amirhossein; Simental-Mendía, Luis E.; Mikhailidis, Dimitri P.; Pirro, Matteo; Banach, Maciej; Sirtori, Cesare R.; Ruscica, Massimiliano; Reiner, Željko

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Sahebkar, A., Simental Mendía, L. E., Mikhailidis, D. P., Pirro, M., Banach, M., Sirtori, C. R. ... Reiner, Ž. (2018). Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Lipidology, 12. (3), 801-809. doi: 10.1016/j.jacl.2018.01.008

Sahebkar, Amirhossein, et al. "Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials." Journal of Clinical Lipidology, vol. 12, br. 3, 2018, str. 801-809. https://doi.org/10.1016/j.jacl.2018.01.008

Sahebkar, Amirhossein, Luis E. Simental Mendía, Dimitri P. Mikhailidis, Matteo Pirro, Maciej Banach, Cesare R. Sirtori, Massimiliano Ruscica i Željko Reiner. "Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials." Journal of Clinical Lipidology 12, br. 3 (2018): 801-809. https://doi.org/10.1016/j.jacl.2018.01.008

Sahebkar, A., et al. (2018) 'Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials', Journal of Clinical Lipidology, 12(3), str. 801-809. doi: 10.1016/j.jacl.2018.01.008

Sahebkar A, Simental Mendía LE, Mikhailidis DP, Pirro M, Banach M, Sirtori CR, i sur.. Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Lipidology [Internet]. 2018. [pristupljeno 12.05.2024.];12(3):801-809. doi: 10.1016/j.jacl.2018.01.008

A. Sahebkar, et al., "Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials", Journal of Clinical Lipidology, vol. 12, br. 3, str. 801-809, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:802520. [Citirano: 12.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:802520
Podaci o radu
Naslov (engleski)Effect of statin therapy on plasma apolipoprotein CIII concentrations: A systematic review and meta-analysis of randomized controlled trials
AutorAmirhossein Sahebkar
AutorLuis E. Simental-Mendía
AutorDimitri P. Mikhailidis
AutorMatteo Pirro
AutorMaciej Banach
AutorCesare R. Sirtori
AutorMassimiliano Ruscica
AutorŽeljko Reiner
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Statins are well-established low- density lipoprotein cholesterol lowering drugs. Elevated apolipoprotein CIII (Apo CIII) levels are associated with elevated triglyceride-rich particles, which are also considered to be a possible risk factor for cardiovascular disease. OBJECTIVE: The aim of this meta-analysis of randomized placebo-controlled clinical trials was to assess the effect of statins on Apo CIII concentrations. METHODS: Randomized placebo-controlled trials investigating the impact of statin treatment on cholesterol lowering that include lipoprotein measurement were searched in PubMed, MEDLINE, Scopus, Web of Science, and Google Scholar databases (up to July 31, 2017). A random- effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on Apo CIII concentrations. RESULTS: This meta-analysis of data from 6 randomized placebo-controlled clinical trials (10 statin arms) involving 802 subjects showed that statin therapy significantly decreased circulating Apo CIII concentrations (weighted mean difference [WMD]: -2.71, 95% confidence interval [CI]: -3.74 to -1.68, P < .001 ; I-2: 73.83%). The effect size was robust in the leave-one-out sensitivity analysis and not driven by any single study. Subgroup analysis showed a reduction of Apo CIII concentrations by atorvastatin (WMD: -4.74, 95% CI:-3.74 to -1.68, P =.002 ; I-2: 84.02%), rosuvastatin (WMD: -2.68, 95% CI: -4.52 to-0.84, P = .004 ; I-2: 0%), and lovastatin (WMD: -1.64, 95% CI: -2.22 to -1.07, P < .001 ; I-2: 0%). CONCLUSION: This meta-analysis suggests that statin treatment significantly reduces plasma Apo CIII levels. (C) 2018 National Lipid Association. All rights reserved
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Lipidology
Brojčani podacivol. 12, br. 3, str. 801-809
p-ISSN1933-2874
DOIhttps://doi.org/10.1016/j.jacl.2018.01.008
URN:NBNurn:nbn:hr:184:802520
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/1050169
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-17 17:51:21