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NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
European Journal of Immunology, 47 (2017), 4; 692-703. https://doi.org/10.1002/eji.201646756
Diab, M.; Glasner, A.; Issacson, B.; Bar-On, Yotam; Drori, Y.; Yamin, R.; Duev-Cohen, A.; Danziger, O.; Zamostiano, R.; Mandelboim, M.; Jonjić, Stipan; Bacharach, E.; Mandelboim, O.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Diab, M., Glasner, A., Issacson, B., Bar On, Y., Drori, Y., Yamin, R. ... Mandelboim, O. (2017). NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.. European Journal of Immunology, 47. (4), 692-703. doi: 10.1002/eji.201646756

Diab, M., et al. "NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.." European Journal of Immunology, vol. 47, br. 4, 2017, str. 692-703. https://doi.org/10.1002/eji.201646756

Diab, M., A. Glasner, B. Issacson, Yotam Bar On, Y. Drori, R. Yamin, A. Duev Cohen, et al. "NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.." European Journal of Immunology 47, br. 4 (2017): 692-703. https://doi.org/10.1002/eji.201646756

Diab, M., et al. (2017) 'NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.', European Journal of Immunology, 47(4), str. 692-703. doi: 10.1002/eji.201646756

Diab M, Glasner A, Issacson B, Bar On Y, Drori Y, Yamin R, i sur.. NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.. European Journal of Immunology [Internet]. 2017. [pristupljeno 15.05.2024.];47(4):692-703. doi: 10.1002/eji.201646756

M. Diab, et al., "NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.", European Journal of Immunology, vol. 47, br. 4, str. 692-703, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:535729. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:535729
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Naslov (engleski)NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
AutorM. Diab
AutorA. Glasner
AutorB. Issacson
AutorYotam Bar-On
AutorY. Drori
AutorR. Yamin
AutorA. Duev-Cohen
AutorO. Danziger
AutorR. Zamostiano
AutorM. Mandelboim
AutorStipan Jonjić
AutorE. Bacharach
AutorO. Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Natural killer (NK) cells are capable of killing various pathogens upon stimulation of activating receptors. Human metapneumovirus (HMPV) is a respiratory virus, which was discovered in 2001 and is responsible for acute respiratory tract infection in infants and children worldwide. HMPV infection is very common, infecting around 70% of all children under the age of five. Under immune suppressive conditions, HMPV infection can be fatal. Not much is known on how NK cells respond to HMPV. In this study, using reporter assays and NK-cell cytotoxicity assays performed with human and mouse NK cells, we demonstrated that the NKp46-activating receptor and its mouse orthologue Ncr1, both members of the natural cytotoxicity receptor (NCR) family, recognized an unknown ligand expressed by HMPV-infected human cells. We demonstrated that MHC class I is upregulated and MICA is downregulated upon HMPV infection. We also characterized mouse NK-cell phenotype in the blood and the lungs of HMPV-infected mice and found that lung NK cells are more activated and expressing NKG2D, CD43, CD27, KLRG1, and CD69 compared to blood NK cells regardless of HMPV infection. Finally, we demonstrated, using Ncr1-deficient mice, that NCR1 plays a critical role in controlling HMPV infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 47, br. 4, str. 692-703
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201646756
URN:NBNurn:nbn:hr:184:535729
Datum objave publikacije2017
ProjektŠifra: 062-0621261-1263
Naziv (hrvatski): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Naziv (engleski): Molecular mechanisms of immune evasion by cytomegalovirus
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/867231
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-02-28 14:04:15