prikaz prve stranice dokumenta Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity
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Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity
DNA Repair, 90 (2020); 102848. https://doi.org/10.1016/j.dnarep.2020.102848
Svetec Miklenić, Marina; Gatalica, Nikolina; Matanović, Angela; Žunar, Bojan; Štafa, Anamarija; Lisnić, Berislav; Svetec, Ivan Krešimir

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Svetec Miklenić, M., Gatalica, N., Matanović, A., Žunar, B., Štafa, A., Lisnić, B. i Svetec, I. K. (2020). Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity. DNA Repair, 90.. doi: 10.1016/j.dnarep.2020.102848

Svetec Miklenić, Marina, et al. "Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity." DNA Repair, vol. 90, 2020. https://doi.org/10.1016/j.dnarep.2020.102848

Svetec Miklenić, Marina, Nikolina Gatalica, Angela Matanović, Bojan Žunar, Anamarija Štafa, Berislav Lisnić i Ivan Krešimir Svetec. "Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity." DNA Repair 90 (2020). https://doi.org/10.1016/j.dnarep.2020.102848

Svetec Miklenić, M., et al. (2020) 'Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity', DNA Repair, 90. doi: 10.1016/j.dnarep.2020.102848

Svetec Miklenić M, Gatalica N, Matanović A, Žunar B, Štafa A, Lisnić B, i sur.. Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity. DNA Repair [Internet]. 2020. [pristupljeno 02.12.2024.];90. doi: 10.1016/j.dnarep.2020.102848

M. Svetec Miklenić, et al., "Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity", DNA Repair, vol. 90, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:046119. [Citirano: 02.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:046119
Podaci o radu
Naslov (engleski)Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity
AutorMarina Svetec Miklenić
MBZ: 314102
AutorNikolina Gatalica
AutorAngela Matanović
MBZ: 383924
AutorBojan Žunar
MBZ: 333226
AutorAnamarija Štafa
MBZ: 262126
AutorBerislav Lisnić
AutorIvan Krešimir Svetec
MBZ: 210466
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Palindromic sequences in DNA can instigate genetic recombination and genome instability, which can result in devastating conditions such as the Emmanuel syndrome. Palindrome recombinogenicity increases with its size and sequence similarity between palindrome arms, while quasipalindromes with long spacers are less recombinogenic. However, the minimal spacer length, which could reduce or abolish palindrome recombinogenicity in the eukaryotic genome, was never determined. Therefore, we constructed a series of palindromes containing spacers of lengths ranging from 0 (perfect palindrome) to 10 bp and tested their recombinogenicity in yeast Saccharomyces cerevisiae. We found that a 7 bp spacer significantly reduces 126 bp palindrome recombinogenicity, while a 10 bp spacer completely stabilizes palindromes up to 150 bp long. Additionally, we showed that palindrome stimulated recombination rate is not dependent on Mus81 and Yen1 endonucleases. We also compared the recombinogenicity of a perfect 126 bp palindrome and a corresponding quasipalindrome consisting of the same palindrome arms with a stabilising 10 bp spacer in sgs1Δ and rad27Δ backgrounds, since both Sgs1 helicase and Rad27 endonuclease are implicated in preventing hairpin formation at palindromic sequences during replication.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDNA Repair
Brojčani podacivol. 90, 102848
p-ISSN1568-7864
DOIhttps://doi.org/10.1016/j.dnarep.2020.102848
URN:NBNurn:nbn:hr:184:046119
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1112340
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-02 12:29:09