prikaz prve stranice dokumenta Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications
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Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications
Clinical rheumatology, 35 (2016), 10; 2565-2571. https://doi.org/10.1007/s10067-016-3377-8
Čulić, Ognjen; Cordero, Mario D.; Žanić- Grubišić, Tihana; Somborac-Bačura, Anita; Batičić Pučar, Lara; Detel, Dijana; Varljen, Jadranka; Barišić, Karmela

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Čulić, O., Cordero, M. D., Žanić Grubišić, T., Somborac Bačura, A., Batičić Pučar, L., Detel, D. ... Barišić, K. (2016). Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications. Clinical rheumatology, 35. (10), 2565-2571. doi: 10.1007/s10067-016-3377-8

Čulić, Ognjen, et al. "Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications." Clinical rheumatology, vol. 35, br. 10, 2016, str. 2565-2571. https://doi.org/10.1007/s10067-016-3377-8

Čulić, Ognjen, Mario D. Cordero, Tihana Žanić Grubišić, Anita Somborac Bačura, Lara Batičić Pučar, Dijana Detel, Jadranka Varljen i Karmela Barišić. "Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications." Clinical rheumatology 35, br. 10 (2016): 2565-2571. https://doi.org/10.1007/s10067-016-3377-8

Čulić, O., et al. (2016) 'Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications', Clinical rheumatology, 35(10), str. 2565-2571. doi: 10.1007/s10067-016-3377-8

Čulić O, Cordero MD, Žanić Grubišić T, Somborac Bačura A, Batičić Pučar L, Detel D, i sur.. Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications. Clinical rheumatology [Internet]. 2016. [pristupljeno 23.12.2024.];35(10):2565-2571. doi: 10.1007/s10067-016-3377-8

O. Čulić, et al., "Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications", Clinical rheumatology, vol. 35, br. 10, str. 2565-2571, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:388913. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:388913
Podaci o radu
Naslov (engleski)Serum activities of adenosine deaminase, dipeptidyl peptidase IV and prolyl endopeptidase in patients with fibromyalgia: diagnostic implications
AutorOgnjen Čulić
MBZ: 137063
AutorMario D. Cordero
AutorTihana Žanić- Grubišić
MBZ: 80883
AutorAnita Somborac-Bačura
MBZ: 298345
AutorLara Batičić Pučar
AutorDijana Detel
AutorJadranka Varljen
AutorKarmela Barišić
MBZ: 187331
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Fibromyalgia (FM) is a chronic pain syndrome with number of symptoms that present challenge in terms of diagnosis and treatment. Patients with FM show abnormal profile of purines in plasma. In this work, we measured serum activities of enzymes involved in purine metabolism, namely total adenosine deaminase (ADE) and its isoforms (ADE1 and ADE2), ecto- ATPase, and 5′- nucleotidase (5′-NT). We also measured activity of dipeptidyl peptidase IV (DPPIV) and prolyl endopeptidase (PEP). Spectrophotometric and fluorometric methods were used for enzyme activity determinations. Enzyme activities were measured in sera of 24 patients with FM that were not undergoing pharmacological treatment during the study. Control group comprised 32 healthy control subjects. Significantly higher activities of total ADE (P = 0.025) and ADE2 (P = 0.011) were observed in FM patients, while no significant differences in ADE1, ecto-ATPase, and 5′-NT activities (P > 0.05) were found when compared to healthy controls. Moreover, increase in the activity of DPPIV (P = 0.015) and lower activity of PEP (P = 0.011) were also found in the FM group. ROC analysis pointed to different diagnostic sensitivities/specificities for individual enzyme activities measured as follows: ADE (50.0/87.5), ADE2 (41.7/90.6), DPPIV (62.5/71.9), and PEP (83.3/62.5). ADE2 and PEP were shown to be independent predictors of FM, while combination of the two gives AUC of 0.786 (95 % confidence interval of 0.656–0.885, P < 0.05). Our results are showing that serum activities of ADE2 and PEP could be useful as biomarkers for FM diagnosis. However, relatively low diagnostic sensitivity of ADE2 and specificity of PEP must be taken into account.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical rheumatology
Brojčani podacivol. 35, br. 10, str. 2565-2571
p-ISSN0770-3198
DOIhttps://doi.org/10.1007/s10067-016-3377-8
URN:NBNurn:nbn:hr:184:388913
Datum objave publikacije2016
URL dokumentahttp://bib.irb.hr/836837
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-08 14:47:03