Objective: The aim of this study was to analyze the trend of the incidence of HIV and AIDS in the Primorsko-goranska County in the period 1985-2014. Materials and Methods: We have used the data of the Register for HIV / AIDS for the Primorsko-goranska County, obtained from the Epidemiology department of the Institute of Public Health of Primorsko-goranska County. To process the data, we used the computer program Microsoft Excel. Results: With the analysis of the obtained data, it was found that in the period 1985-2014 there were 130 reported cases of HIV infection in the Primorsko-goranska county. 77% of the total number of patients were men, and the remaining 23% were women. Most patients belong to the age group 30-49 years, 77 of 130 patients. The most common route of transmission is sexual transmission, in 108 of the 130 cases, mostly in promiscuous person. The following are heterosexual and bisexual people, furthermore intravenous drug users, hemophiliacs and children of HIV-positive mothers. In 5 cases the most likely route of transmission is unknown. In this monitored period, there are 31 registered deaths of people with HIV infection. From 1986 to 2014 there were a total of 45 cases of people with AIDS. 80% of the total number of patients were men and the rest of 20% were women. Most patients belong to the age group 30-49 years, 32 people from 45, as well as in HIV infection. And also the most likely routes of transmission are consistent with the ways of HIV infection, so the most common route of transmission is sexual, in 37 of 45 cases. During this period, there were 25 registered deaths of people with AIDS. Conclusion: This analysis gives an insight into the state of HIV and AIDS in the Primorsko-goranska County. It was found that there is a low-level epidemic.