prikaz prve stranice dokumenta The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
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The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
Nature immunology, 20 (2019); 1012-1022. https://doi.org/10.1038/s41590-019-0417-y
Mattiola, Irene; Tomay, Federica; De Pizzol, Maria; Silva-Gomes, Rita; Savino, Benedetta; Gulić, Tamara; Doni, Andrea; Lonardi, Silvia; Boutet, Marie Astrid; Nerviani, Alessandra; Carriero, Roberta; Molgora, Martina; Stravalaci, Matteo; Morone, Diego; Shalova, Irina N.; Lee, Yunquin; Biswas, Subhra K.; Mantovani, Giovanna; Sironi, Marina; Pitzalis, Costantino; Vermi, William; Bottazzi, Barbara; Mantovani, Alberto; Locati, Massimo Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Mattiola, I., Tomay, F., De Pizzol, M., Silva Gomes, R., Savino, B., Gulić, T. ... Locati, M. (2019). The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature immunology, 20., 1012-1022. doi: 10.1038/s41590-019-0417-y

Mattiola, Irene, et al. "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis." Nature immunology, vol. 20, 2019, str. 1012-1022. https://doi.org/10.1038/s41590-019-0417-y

Mattiola, Irene, Federica Tomay, Maria De Pizzol, Rita Silva Gomes, Benedetta Savino, Tamara Gulić, Andrea Doni, et al. "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis." Nature immunology 20 (2019): 1012-1022. https://doi.org/10.1038/s41590-019-0417-y

Mattiola, I., et al. (2019) 'The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis', Nature immunology, 20, str. 1012-1022. doi: 10.1038/s41590-019-0417-y

Mattiola I, Tomay F, De Pizzol M, Silva Gomes R, Savino B, Gulić T, i sur.. The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis. Nature immunology [Internet]. 2019. [pristupljeno 15.05.2024.];20:1012-1022. doi: 10.1038/s41590-019-0417-y

I. Mattiola, et al., "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis", Nature immunology, vol. 20, str. 1012-1022, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:537822. [Citirano: 15.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:537822
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Naslov (engleski)The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis
AutorIrene Mattiola
AutorFederica Tomay
AutorMaria De Pizzol
AutorRita Silva-Gomes
AutorBenedetta Savino
AutorTamara Gulić
AutorAndrea Doni
AutorSilvia Lonardi
AutorMarie Astrid Boutet
AutorAlessandra Nerviani
AutorRoberta Carriero
AutorMartina Molgora
AutorMatteo Stravalaci
AutorDiego Morone
AutorIrina N. Shalova
AutorYunquin Lee
AutorSubhra K. Biswas
AutorGiovanna Mantovani
AutorMarina Sironi
AutorCostantino Pitzalis
AutorWilliam Vermi
AutorBarbara Bottazzi
AutorAlberto Mantovani
AutorMassimo Locati
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell–mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell–mediated resistance to metastasis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature immunology
Brojčani podacivol. 20, str. 1012-1022
p-ISSN1529-2908
DOIhttps://doi.org/10.1038/s41590-019-0417-y
URN:NBNurn:nbn:hr:184:537822
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1050153
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-11 17:17:56