prikaz prve stranice dokumenta Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids
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Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids
Current Vascular Pharmacology, 17 (2019), 5; 507-516. https://doi.org/10.2174/1570161117666190705141152
M’baya-Moutoula, Eleonore; Marchand, Alexandre; Six, Isabelle; Bahrar, Noura; Ćelić, Tanja; Mougenot, Nathalie; Maitrias, Pierre; Massy, Ziad A.; Lompreh, Anne-Marie; Metzinger, Laurent; Meuth, Valérie Metzinger-Le

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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M’baya Moutoula, E., Marchand, A., Six, I., Bahrar, N., Ćelić, T., Mougenot, N. ... Meuth, V. M. L. (2019). Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids. Current Vascular Pharmacology, 17. (5), 507-516. doi: 10.2174/1570161117666190705141152

M’baya Moutoula, Eleonore, et al. "Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids." Current Vascular Pharmacology, vol. 17, br. 5, 2019, str. 507-516. https://doi.org/10.2174/1570161117666190705141152

M’baya Moutoula, Eleonore, Alexandre Marchand, Isabelle Six, Noura Bahrar, Tanja Ćelić, Nathalie Mougenot, Pierre Maitrias, et al. "Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids." Current Vascular Pharmacology 17, br. 5 (2019): 507-516. https://doi.org/10.2174/1570161117666190705141152

M’baya Moutoula, E., et al. (2019) 'Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids', Current Vascular Pharmacology, 17(5), str. 507-516. doi: 10.2174/1570161117666190705141152

M’baya Moutoula E, Marchand A, Six I, Bahrar N, Ćelić T, Mougenot N, i sur.. Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids. Current Vascular Pharmacology [Internet]. 2019. [pristupljeno 25.12.2024.];17(5):507-516. doi: 10.2174/1570161117666190705141152

E. M’baya Moutoula, et al., "Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids", Current Vascular Pharmacology, vol. 17, br. 5, str. 507-516, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:088359. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:088359
Podaci o radu
Naslov (engleski)Inhibition of miR-223 expression using a sponge strategy decreases restenosis in rat injured carotids
AutorEleonore M’baya-Moutoula
AutorAlexandre Marchand
AutorIsabelle Six
AutorNoura Bahrar
AutorTanja Ćelić
AutorNathalie Mougenot
AutorPierre Maitrias
AutorZiad A. Massy
AutorAnne-Marie Lompreh
AutorLaurent Metzinger
AutorValérie Metzinger-Le Meuth
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Objective: Restenosis is a frequent complication of angioplasty. It consists of a neointimal hyperplasia resulting from progression and migration of vascular smooth muscle cells (VSMC) into the vessel lumen. microRNA miR-223 has recently been shown to be involved in cardiovascular diseases including atherosclerosis, vascular calcification and arterial thrombosis. In this study, our aim was to assess the impact of miR-223 modulation on restenosis in a rat model of carotid artery after balloon injury. Methods: The over and down-expression of miR-223 was induced by adenoviral vectors, containing either a pre-miR-223 sequence allowing artificial miR-223 expression or a sponge sequence, trapping the native microRNA, respectively. Restenosis was quantified on stained rat carotid sections. Results: In vitro, three mRNA (Myocyte Enhancer Factor 2C (MEF2C), Ras homolog gene family, member B (RhoB) and Nuclear factor 1 A-type (NFIA)) reported as miR-223 direct targets and known to be implicated in VSMC differentiation and contractility were studied by RT-qPCR. Our findings showed that down-expression of miR-223 significantly reduced neointimal hyperplasia by 44% in carotids, and was associated with a 2-3- fold overexpression of MEF2C, RhoB and NFIA in a murine monocyte macrophage cell line, RAW 264.7 cells. Conclusion: Down-regulating miR-223 could be a potential therapeutic approach to prevent restenosis after angioplasty.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Vascular Pharmacology
Brojčani podacivol. 17, br. 5, str. 507-516
p-ISSN1570-1611
DOIhttps://doi.org/10.2174/1570161117666190705141152
URN:NBNurn:nbn:hr:184:088359
Datum objave publikacije2019
URL dokumentahttp://bib.irb.hr/1053178
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-15 08:25:32