prikaz prve stranice dokumenta Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection
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Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection
Infection and Immunity, 65 (1997), 5; 1754-1760. https://doi.org/10.1128/iai.65.5.1754-1760.1997
Rukavina, Tomislav; Tíćac, Brigita; Šuša, Miodrag; Jendrike, N; Jonjíć, Stipan; Lučin, Pero; Marre, R; Doríć, Miljenko; Trautmann, M

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Rukavina, T., Tíćac, B., Šuša, M., Jendrike, N., Jonjíć, S., Lučin, P. ... Trautmann, M. (1997). Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. Infection and Immunity, 65. (5), 1754-1760. doi: 10.1128/iai.65.5.1754-1760.1997

Rukavina, Tomislav, et al. "Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection." Infection and Immunity, vol. 65, br. 5, 1997, str. 1754-1760. https://doi.org/10.1128/iai.65.5.1754-1760.1997

Rukavina, Tomislav, Brigita Tíćac, Miodrag Šuša, N Jendrike, Stipan Jonjíć, Pero Lučin, R Marre, Miljenko Doríć i M Trautmann. "Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection." Infection and Immunity 65, br. 5 (1997): 1754-1760. https://doi.org/10.1128/iai.65.5.1754-1760.1997

Rukavina, T., et al. (1997) 'Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection', Infection and Immunity, 65(5), str. 1754-1760. doi: 10.1128/iai.65.5.1754-1760.1997

Rukavina T, Tíćac B, Šuša M, Jendrike N, Jonjíć S, Lučin P, i sur.. Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection. Infection and Immunity [Internet]. 05.1997. [pristupljeno 07.05.2024.];65(5):1754-1760. doi: 10.1128/iai.65.5.1754-1760.1997

T. Rukavina, et al., "Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection", Infection and Immunity, vol. 65, br. 5, str. 1754-1760, Svibanj 1997. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:879758. [Citirano: 07.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:879758
Podaci o radu
Naslov (engleski)Protective effect of antilipopolysaccharide monoclonal antibody in experimental Klebsiella infection
AutorTomislav Rukavina
AutorBrigita Tíćac
AutorMiodrag Šuša
AutorN Jendrike
AutorStipan Jonjíć
AutorPero Lučin
AutorR Marre
AutorMiljenko Doríć
AutorM Trautmann
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
An O-antigen-specific murine monoclonal antibody (MAb) directed against an immunodominant epitope expressed on Klebsiella O1, O6, and O8 lipopolysaccharides (LPS) was examined with respect to its binding to nonencapsulated and encapsulated bacterial cells and its ability to protect against lethal murine Klebsiella sepsis. While the MAb (clone Ru-O1, mouse immunoglobulin G2b) bound well to nonencapsulated organisms of the O1 serogroup, binding was significantly, but not completely, abolished by the presence of the K2 capsule. In a model of experimental Klebsiella peritonitis and sepsis induced by a virulent O1:K2 serogroup strain, higher doses of anti-LPS MAb Ru-O1 than of a previously described anticapsular MAb specific for the K2 capsular polysaccharide were needed to provide protection. However, high-dose (40 microg/g of body weight) pretreatment with anti-LPS MAb Ru-O1 significantly reduced bacterial dissemination to various organs as well as macroscopic and histologic pulmonary alterations. Thus, since the number of Klebsiella capsular antigens occurring in clinical material is too large to be completely "covered" by a K-antigen-specific hyperimmunoglobulin preparation, O-antigen-specific antibodies may supplement K-antigen-specific immunoprophylaxis and -therapy of clinical Klebsiella infection.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInfection and Immunity
Brojčani podacivol. 65, br. 5, str. 1754-1760
p-ISSN0019-9567
e-ISSN1098-5522
DOIhttps://doi.org/10.1128/iai.65.5.1754-1760.1997
URN:NBNurn:nbn:hr:184:879758
Datum objave publikacije1997-05
URL dokumentahttps://journals.asm.org/doi/10.1128/iai.65.5.1754-1760.1997
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-17 21:51:40