prikaz prve stranice dokumenta Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia
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Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia
Biological Trace Element Research, (2022); https://doi.org/10.1007/s12011-021-03090-6
Linšak, Željko; Gobin, Ivana; Linšak, Dijana Tomić; Broznić, Dalibor

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Linšak, Ž., Gobin, I., Linšak, D. T. i Broznić, D. (2022). Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia. Biological Trace Element Research. doi: 10.1007/s12011-021-03090-6

Linšak, Željko, et al. "Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia." Biological Trace Element Research, 2022. https://doi.org/10.1007/s12011-021-03090-6

Linšak, Željko, Ivana Gobin, Dijana Tomić Linšak i Dalibor Broznić. "Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia." Biological Trace Element Research (2022). https://doi.org/10.1007/s12011-021-03090-6

Linšak, Ž., et al. (2022) 'Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia', Biological Trace Element Research. doi: 10.1007/s12011-021-03090-6

Linšak Ž, Gobin I, Linšak DT, Broznić D. Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia. Biological Trace Element Research [Internet]. 03.01.2022. [pristupljeno 28.04.2024.]. doi: 10.1007/s12011-021-03090-6

Ž. Linšak, I. Gobin, D. T. Linšak i D. Broznić, "Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia", Biological Trace Element Research, Siječanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:688274. [Citirano: 28.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:688274
Podaci o radu
Naslov (engleski)Effects of Long-Term Lead Exposure on Antioxidant Enzyme Defense System in Organs of Brown Hare (Lepus europaeus Pallas) as a Bioindicator of Environmental Pollution in Croatia
AutorŽeljko Linšak
AutorIvana Gobin
AutorDijana Tomić Linšak
AutorDalibor Broznić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za mikrobiologiju i parazitologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Zdravstvena ekologija
Sažetak (engleski)
Abstract In Croatia, Podravina is a well-known lead-polluted region due to the intensive exploitation of natural gas, a highly developed agricultural industry, and a traffic hub with several heavily traveled roads. It represents a natural environment with a great variety of wildlife, especially hares (Lepus europaeus Pallas), which may serve as an indicator for environmental quality assessment. This study was conducted to estimate the bioaccumulation of lead in hare liver, kidney, muscle, and brain during long-term exposure and its impact on the oxidative status of the organism and to investigate a possible lead exchange ionic mechanism in the brain. In the organs of two hare groups (experimental from polluted area and control from the island of Krk), Ca, Fe, Mg, Na, lead concentrations, and antioxidant enzyme defense system were analyzed. The accumulation of lead was highest in the brain (3.7-fold higher compared to the control group) and lowest in the liver (1.6-fold higher compared to the control group). Kendall-Tau and multiple regression analysis showed that the increased lead content caused a stronger exchange of Ca and Na ions in the brain. We proposed that lead either mobilizes intracellular cation stores or causes competitive displacement of Ca from the binding site in intoxicated cells. A linear predictive model for cell intoxication by lead was proposed, where GPx and SOD were predominantly influenced by long-term lead exposure. The presented results showed that long-term lead exposure in hares negatively affected their oxidative status and caused the strongest toxicity in the brain and muscles, making their survival and/or population vulnerable.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objavePrihvaćen za objavljivanje
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiological Trace Element Research
p-ISSN0163-4984
e-ISSN1559-0720
DOIhttps://doi.org/10.1007/s12011-021-03090-6
URN:NBNurn:nbn:hr:184:688274
Datum objave publikacije2022-01-03
ProjektŠifra: UNIRI-biomed-18-155-1304
Naziv (hrvatski): Razvoj novih analitičkih metoda u analizi ostataka imidakloprida i njegovih razgradnih produkata u tlima maslinika Primorsko-goranske županije
Naziv (engleski): Development of new analytical methods in the analysis of the imidacloprid residues and its degradation products in the olive orchard soils of Primorsko-goranska County
Voditelj: Dalibor Broznić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: 062-0621341-0061
Naziv (hrvatski): Masne kiseline i polifenoli u regeneraciji i reparaciji tkiva.
Naziv (engleski): Fatty acids and polyphenols in tissue regeneration and reparation.
Voditelj: Čedomila Milin
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
ProjektŠifra: 053-0532400-2362
Naziv (hrvatski): Ekotoksikološka istraživanja u divljači
Naziv (engleski): Ecotoxicological investigations in game
Voditelj: Emil Srebočan
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttps://link.springer.com/10.1007/s12011-021-03090-6
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-05 15:31:00