Naslov (engleski) COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)
Autor Livio Pagano
Autor Jon Salmanton-García
Autor Francesco Marchesi
Autor Alessandro Busca
Autor Paolo Corradini
Autor Martin Hoenigl
Autor Nikolai Klimko
Autor Philipp Koehler
Autor Antonio Pagliuca
Autor Francesco Passamonti
Autor Luisa Verga
Autor Benjamin Víšek
Autor Osman Ilhan
Autor Gianpaolo Nadali
Autor Barbora Weinbergerová
Autor Raúl Córdoba-Mascuñano
Autor Monia Marchetti
Autor Graham P. Collins
Autor Francesca Farina
Autor Chiara Cattaneo
Autor Alba Cabirta
Autor Maria Gomes-Silva
Autor Federico Itri
Autor Jaap van Doesum
Autor Marie-Pierre Ledoux
Autor Martin Čerňan
Autor Ozren Jakšić
Autor Rafael F. Duarte
Autor Gabriele Magliano
Autor Ali S. Omrani
Autor Nicola S. Fracchiolla
Autor Austin Kulasekararaj
Autor Toni Valković
Autor Christian Bjørn Poulsen
Autor Marina Machado
Autor Andreas Glenthøj
Autor Igor Stoma
Autor Zdeněk Ráčil
Autor Klára Piukovics
Autor Milan Navrátil
Autor Ziad Emarah
Autor Uluhan Sili
Autor Johan Maertens
Autor Ola Blennow
Autor Rui Bergantim
Autor Carolina García-Vidal
Autor Lucia Prezioso
Autor Anna Guidetti
Autor Maria Ilaria del Principe
Autor Marina Popova
Autor Nick de Jonge
Autor Irati Ormazabal-Vélez
Autor Noemí Fernández
Autor Iker Falces-Romero
Autor Annarosa Cuccaro
Autor Stef Meers
Autor Caterina Buquicchio
Autor Darko Antić
Autor Murtadha Al- Khabori
Autor Ramón García-Sanz
Autor Monika M. Biernat
Autor Maria Chiara Tisi
Autor Ertan Sal
Autor Laman Rahimli
Autor Natasa Čolović
Autor Martin Schönlein
Autor Maria Calbacho
Autor Carlo Tascini
Autor Carolina Miranda-Castillo
Autor Nina Khanna
Autor Gustavo-Adolfo Méndez
Autor Verena Petzer
Autor Jan Novák
Autor Caroline Besson
Autor Rémy Duléry
Autor Sylvain Lamure
Autor Marcio Nucci
Autor Giovanni Zambrotta
Autor Pavel Žák
Autor Guldane Cengiz Seval
Autor Valentina Bonuomo
Autor Jiří Mayer
Autor Alberto López-García
Autor Maria Vittoria Sacchi
Autor Stephen Booth
Autor Fabio Ciceri
Autor Margherita Oberti
Autor Marco Salvini
Autor Macarena Izuzquiza
Autor Raquel Nunes-Rodrigues
Autor Emanuele Ammatuna
Autor Aleš Obr
Autor Raoul Herbrecht
Autor Lucía Núñez-Martín-Buitrago
Autor Valentina Mancini
Autor Hawraa Shwaylia
Autor Mariarita Sciumè
Autor Jenna Essame
Autor Marietta Nygaard
Autor Josip Batinić
Autor Yung Gonzaga
Autor Isabel Regalado-Artamendi
Autor Linda Katharina Karlsson
Autor Maryia Shapetska
Autor Michaela Hanakova
Autor Shaimaa El-Ashwah
Autor Zita Borbényi
Autor Gökçe Melis Çolak
Autor Anna Nordlander
Autor Giulia Dragonetti
Autor Alessio Maria Edoardo Maraglino
Autor Amelia Rinaldi
Autor Cristina De Ramón- Sánchez
Autor Oliver A. Cornely
Autor Olimpia Finizio
Autor Rita Fazzi
Autor Giuseppe Sapienza
Autor Adrien Chauchet
Autor Jens Van Praet
Autor Juergen Prattes
Autor Michelina Dargenio
Autor Cédric Rossi
Autor Ayten Shirinova
Autor Sandra Malak
Autor Agostino Tafuri
Autor Hans-Beier Ommen
Autor Serge Bologna
Autor Reham Abdelaziz Khedr
Autor Sylvain Choquet
Autor Bertrand Joly
Autor M. Mansour Ceesay
Autor Laure Philippe
Autor Chi Shan Kho
Autor Maximilian Desole
Autor Panagiotis Tsirigotis
Autor Vladimir Otašević
Autor Davimar M. M. Borducchi
Autor Anastasia Antoniadou
Autor Javid Gaziev
Autor Muna A. Almaslamani
Autor Nicole García-Poutón
Autor Giovangiacinto Paterno
Autor Andrea Torres-López
Autor Giuseppe Tarantini
Autor Sibylle Mellinghoff
Autor Stefanie Gräfe
Autor Niklas Börschel
Autor Jakob Passweg
Autor Maria Merelli
Autor Aleksandra Barać
Autor Dominik Wolf
Autor Mohammad Usman Shaikh
Autor Catherine Thiéblemont
Autor Sophie Bernard
Autor Vaneuza Araújo Moreira Funke
Autor Etienne Daguindau
Autor Sofya Khostelidi
Autor Fabio Moore Nucci
Autor Juan-Alberto Martín- González
Autor Marianne Landau
Autor Carole Soussain
Autor Cécile Laureana
Autor Karine Lacombe
Autor Milena Kohn
Autor Gunay Aliyeva
Autor Monica Piedimonte
Autor Guillemette Fouquet
Autor Mayara Rêgo
Autor Baerbel Hoell-Neugebauer
Autor Guillaume Cartron
Autor Fernando Pinto
Autor Ana Munhoz Alburquerque
Autor Juliana Passos
Autor Asu Fergun Yilmaz
Autor Ana-Margarita Redondo-Izal
Autor Fevzi Altuntaş
Autor Christopher Heath
Autor Martin Kolditz
Autor Enrico Schalk
Autor Fabio Guolo
Autor Meinolf Karthaus
Autor Roberta Della Pepa
Autor Donald Vinh
Autor Nicolas Noël
Autor Bénédicte Deau Fischer
Autor Bernard Drenou
Autor Maria Enza Mitra
Autor Joseph Meletiadis
Autor Yavuz M. Bilgin
Autor Pavel Jindra
Autor Ildefonso Espigado
Autor Ľuboš Drgoňa
Autor Alexandra Serris
Autor Roberta Di Blasi
Autor Natasha Ali
Kolaboracija EPICOVIDEHA working group
Autorova ustanova Sveučilište u Rijeci Medicinski fakultet (Katedra za internu medicinu)
Znanstveno / umjetničko područje, polje i grana BIOMEDICINA I ZDRAVSTVO Kliničke medicinske znanosti Interna medicina
Znanstveno / umjetničko područje, polje i grana BIOMEDICINA I ZDRAVSTVO Kliničke medicinske znanosti Infektologija
Sažetak (engleski) Background: Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods: The survey was supported by the Scientifc Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confrmed COVID19 observed between March and December 2020. Results: The study sample includes 3801 cases, represented by lymphoproliferative (mainly non- Hodgkin lymphoma n=1084, myeloma n=684 and chronic lymphoid leukemia n=474) and myeloproliferative malignancies (mainly acute myeloid leukemia n=497 and myelodysplastic syndromes n=279). Severe/critical COVID-19 was observed in 63.8% of patients (n=2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate signifcantly decreased between the frst COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value<0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions: This survey confrms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.
Ključne riječi (engleski)
COVID-19
Pandemic
Hematological malignancies
Epidemiology
EHA
Jezik engleski
Vrsta publikacije Znanstveni rad - Izvorni znanstveni rad
Status objave Objavljen
Vrsta recenzije Recenziran - međunarodna recenzija
Verzija publikacije Objavljena verzija rada (izdavačev PDF)
Naslov časopisa Journal of Hematology & Oncology
Brojčani podaci vol. 141, br. 1, 168
p-ISSN 1756-8722
DOI https://doi.org/10.1186/s13045-021-01177-0
URN:NBN urn:nbn:hr:184:532422
Datum objave publikacije 2021
URL dokumenta https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01177-0
Vrsta resursa Tekst
Prava pristupa Otvoreni pristup
Uvjeti korištenja
Datum i vrijeme pohrane 2022-04-06 10:13:47