prikaz prve stranice dokumenta Prevalence of rare F5 variants in general population from Bosnia and Herzegovina
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Prevalence of rare F5 variants in general population from Bosnia and Herzegovina
Molecular Biology Reports, 48 (2021), 6; 5181-5186. https://doi.org/10.1007/s11033-021-06519-2
Ašić, Adna; Salazar, Ramona; Storm, Niels; Doğan, Serkan; Höppner, Wolfgang; Marjanović, Damir; Primorac, Dragan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Ašić, A., Salazar, R., Storm, N., Doğan, S., Höppner, W., Marjanović, D. i Primorac, D. (2021). Prevalence of rare F5 variants in general population from Bosnia and Herzegovina. Molecular Biology Reports, 48. (6), 5181-5186. doi: 10.1007/s11033-021-06519-2

Ašić, Adna, et al. "Prevalence of rare F5 variants in general population from Bosnia and Herzegovina." Molecular Biology Reports, vol. 48, br. 6, 2021, str. 5181-5186. https://doi.org/10.1007/s11033-021-06519-2

Ašić, Adna, Ramona Salazar, Niels Storm, Serkan Doğan, Wolfgang Höppner, Damir Marjanović i Dragan Primorac. "Prevalence of rare F5 variants in general population from Bosnia and Herzegovina." Molecular Biology Reports 48, br. 6 (2021): 5181-5186. https://doi.org/10.1007/s11033-021-06519-2

Ašić, A., et al. (2021) 'Prevalence of rare F5 variants in general population from Bosnia and Herzegovina', Molecular Biology Reports, 48(6), str. 5181-5186. doi: 10.1007/s11033-021-06519-2

Ašić A, Salazar R, Storm N, Doğan S, Höppner W, Marjanović D, i sur.. Prevalence of rare F5 variants in general population from Bosnia and Herzegovina. Molecular Biology Reports [Internet]. 02.07.2021. [pristupljeno 13.05.2024.];48(6):5181-5186. doi: 10.1007/s11033-021-06519-2

A. Ašić, et al., "Prevalence of rare F5 variants in general population from Bosnia and Herzegovina", Molecular Biology Reports, vol. 48, br. 6, str. 5181-5186, Srpanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:960349. [Citirano: 13.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:960349
Podaci o radu
Naslov (engleski)Prevalence of rare F5 variants in general population from Bosnia and Herzegovina
AutorAdna Ašić
AutorRamona Salazar
AutorNiels Storm
AutorSerkan Doğan
AutorWolfgang Höppner
AutorDamir Marjanović
AutorDragan Primorac
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Human gene F5, encoding coagulation factor V, was previously reported to be highly polymorphic. Apart from FV Leiden, several other rare variants have been detected in clinical practice and associated with thrombotic events, especially in cases when patient's phenotype and FV Leiden genotype were not in agreement. In this study, the prevalence of 17 rare F5 variants has been studied on a sample of 130 healthy adult individuals from the general Bosnian-Herzegovinian population. DNA was isolated from buccal swab samples, while genotyping was performed using MALDI-TOF MS method. The results have shown that Asp2194Gly and Met2120Thr are polymorphic in the study population with minor allele frequencies of 0.077 and 0.073, respectively. Additionally, these two variants were mutually exclusive with FV Leiden and none of them was positively associated with participants' family history of cardiovascular or cerebrovascular diseases. While the obtained results are in agreement with previously reported data for the general Caucasian populations, it is worth noting that only two rare F5 variants were detected in the study population, albeit at considerable frequencies. Still, scientific information on rare F5 variants is rather scarce and further studies aiming to assess functional importance of these variants, as well as their role as prothrombotic factors are necessary.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecular Biology Reports
Brojčani podacivol. 48, br. 6, str. 5181-5186
p-ISSN0301-4851
e-ISSN1573-4978
DOIhttps://doi.org/10.1007/s11033-021-06519-2
URN:NBNurn:nbn:hr:184:960349
Datum objave publikacije2021-07-02
URL dokumentahttps://link.springer.com/10.1007/s11033-021-06519-2
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-04-07 13:46:11