prikaz prve stranice dokumenta A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice
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A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice
International journal of molecular sciences, 23 (2022); 6237. https://doi.org/10.3390/ijms23116237
Meter, Diana; Racetin, Anita; Vukojević, Katarina; Balog, Marta; Ivić, Vedrana; Zjalić, Milorad; Heffer, Marija; Filipović, Natalija

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Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Meter, D., Racetin, A., Vukojević, K., Balog, M., Ivić, V., Zjalić, M. ... Filipović, N. (2022). A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice. International journal of molecular sciences, 23.. doi: 10.3390/ijms23116237

Meter, Diana, et al. "A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice." International journal of molecular sciences, vol. 23, 2022. https://doi.org/10.3390/ijms23116237

Meter, Diana, Anita Racetin, Katarina Vukojević, Marta Balog, Vedrana Ivić, Milorad Zjalić, Marija Heffer i Natalija Filipović. "A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice." International journal of molecular sciences 23 (2022). https://doi.org/10.3390/ijms23116237

Meter, D., et al. (2022) 'A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice', International journal of molecular sciences, 23. doi: 10.3390/ijms23116237

Meter D, Racetin A, Vukojević K, Balog M, Ivić V, Zjalić M, i sur.. A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice. International journal of molecular sciences [Internet]. 2022. [pristupljeno 03.03.2025.];23. doi: 10.3390/ijms23116237

D. Meter, et al., "A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice", International journal of molecular sciences, vol. 23, 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:536544. [Citirano: 03.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:536544
Podaci o radu
Naslov (engleski)A Lack of GD3 Synthase Leads to Impaired Renal Expression of Connexins and Pannexin1 in St8sia1 Knockout Mice
AutorDiana Meter
AutorAnita Racetin
MBZ: 382526
AutorKatarina Vukojević
MBZ: 287964
AutorMarta Balog
MBZ: 342184
AutorVedrana Ivić
MBZ: 319462
AutorMilorad Zjalić
AutorMarija Heffer
MBZ: 178985
AutorNatalija Filipović
MBZ: 264494
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za molekularnu medicinu i biotehnologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The aim of this study was to determine the effects of altered ganglioside composition on the expression of Cx37, Cx40, Cx43, Cx45, and Panx1 in different kidney regions of St8sia1 gene knockout mice (St8sia1 KO) lacking the GD3 synthase enzyme. Experiments were performed in twelve male 6-month-old mice: four wild-type (C57BL/6-type, WT) and eight St8sia1 KO mice. After euthanasia, kidney tissue was harvested, embedded in paraffin wax, and processed for immunohistochemistry. The expression of... Više connexins and Panx1 was determined in different regions of the kidney: cortex (CTX.), outer stripe of outer medulla (O.S.), inner stripe of outer medulla (IN.S.), and inner medulla (IN.MED.). We determined significantly lower expression of Cx37, Cx40, Cx45, and Panx1 in different parts of the kidneys of St8sia1 KO mice compared with WT. The most consistent decrease was found in the O.S. where all markers (Cx 37, 40, 45 and Panx1) were disrupted in St8si1 KO mice. In the CTX. region, we observed decrease in the expression of Cx37, Cx45, and Panx1, while reduced expression of Cx37 and Panx1 was more specific to IN.S. The results of the present study suggest that deficiency of GD3 synthase in St8sia1 KO mice leads to disruption of renal Cx expression, which is probably related to alteration of ganglioside composition. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational journal of molecular sciences
Brojčani podacivol. 23, 6237
p-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23116237
URN:NBNurn:nbn:hr:184:536544
Datum objave publikacije2022
URL dokumentahttp://bib.irb.hr/1197710
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-06-29 09:29:57
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