prikaz prve stranice dokumenta Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats
  Preuzmi
PDF 312.19 KB
Znanstveni rad - Izvorni znanstveni rad
Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats
Periodicum biologorum, 98 (1996), 1; 107-110. urn:nbn:hr:184:824101
Župan, Gordana; Eraković, Vesna; Mršić, Jasenka; Varljen, Jadranka; Simonić, Ante; Milin, Čedomila

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Župan, G., Eraković, V., Mršić, J., Varljen, J., Simonić, A. i Milin, Č. (1996). Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats. Periodicum biologorum, 98. (1), 107-110. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:824101

Župan, Gordana, et al. "Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats." Periodicum biologorum, vol. 98, br. 1, 1996, str. 107-110. https://urn.nsk.hr/urn:nbn:hr:184:824101

Župan, Gordana, Vesna Eraković, Jasenka Mršić, Jadranka Varljen, Ante Simonić i Čedomila Milin. "Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats." Periodicum biologorum 98, br. 1 (1996): 107-110. https://urn.nsk.hr/urn:nbn:hr:184:824101

Župan, G., et al. (1996) 'Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats', Periodicum biologorum, 98(1), str. 107-110. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:824101 (Datum pristupa: 25.12.2024.)

Župan G, Eraković V, Mršić J, Varljen J, Simonić A, Milin Č. Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats. Periodicum biologorum [Internet]. 1996. [pristupljeno 25.12.2024.];98(1):107-110. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:824101

G. Župan, V. Eraković, J. Mršić, J. Varljen, A. Simonić i Č. Milin, "Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats", Periodicum biologorum, vol. 98, br. 1, str. 107-110, 1996. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:824101. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:824101
Podaci o radu
Naslov (engleski)Effect of nicardipine and amlodipine on the brain free arachidonic acid level in hypoxic rats
AutorGordana Župan
AutorVesna Eraković
AutorJasenka Mršić
AutorJadranka Varljen
AutorAnte Simonić
AutorČedomila Milin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Background and purpose: A number of investigations support the hypothesisthat a common denominator of hypoxic cellular damage in the brain is an increase in intracellular CA2+ concentration that causes degradation of membrane phospholipids and liberation of cerebral free fatty acids, particularly free arachidonic acid (FFA). The aim of our study was to examine the effects of the calcium channel blockers, nicardipine and amlodipine, on the level of the brain FAA in rats exposed to hypoxia. Material and methods: The study was carried out on Hannover-Wistar rats. The drugs tested had been injected 30 minutes prior to hypoxia exposure. Rats were decapitated 15 minutes after losing the righting reflex. The brains of all animals were taken out and were frozen in liquid nitrogen. FAA was quantified using gas chromatography method. Results: The results of our experiments show that an accumulation of the brain FAA occurs during the period of posthypoxic normoxic reoxygenation in hypoxia-exposed rats. The tested doses of nicardipine and amplodipine did not influence the increase in the brain FAA level in hypoxic rats. Conclusions: The inhibition of the CA2+ influx via L-type of voltage-sensitive calcium channels is not sufficient for the attenuation of the release of the brain FAA in hypoxic rats.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPeriodicum biologorum
Brojčani podacivol. 98, br. 1, str. 107-110
p-ISSN0031-5362
URN:NBNurn:nbn:hr:184:824101
Datum objave publikacije1996
URL dokumentahttp://bib.irb.hr/187140
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-11-17 09:12:45