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Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
Metabolites, 13 (2023), 2; 153. https://doi.org/10.3390/metabo13020153
Benić, Ante; Mikašinović, Sanja; Wensveen, Felix M.; Polić, Bojan

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Benić, A., Mikašinović, S., Wensveen, F. M. i Polić, B. (2023). Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites, 13. (2). doi: 10.3390/metabo13020153

Benić, Ante, et al. "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver." Metabolites, vol. 13, br. 2, 2023. https://doi.org/10.3390/metabo13020153

Benić, Ante, Sanja Mikašinović, Felix M. Wensveen i Bojan Polić. "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver." Metabolites 13, br. 2 (2023). https://doi.org/10.3390/metabo13020153

Benić, A., et al. (2023) 'Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver', Metabolites, 13(2). doi: 10.3390/metabo13020153

Benić A, Mikašinović S, Wensveen FM, Polić B. Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites [Internet]. 19.01.2023. [pristupljeno 18.05.2024.];13(2). doi: 10.3390/metabo13020153

A. Benić, S. Mikašinović, F. M. Wensveen i B. Polić, "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver", Metabolites, vol. 13, br. 2, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:452625. [Citirano: 18.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:452625
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Naslov (engleski)Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
AutorAnte Benić
AutorSanja Mikašinović
AutorFelix M. Wensveen
AutorBojan Polić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
In their aspiration to become healthy, people are known to follow extreme diets. However, the acute impact on organs regulating systemic metabolism is not well characterized. Here, we investigated the acute impact of six extreme diets on the liver in mice. Most diets did not lead to clear pathology after short-term feeding. However, two weeks of feeding with a high protein diet (HPD) resulted in an acute increase of liver enzymes in the blood, indicative of liver damage. Histology revealed the formation of necrotic lesions in this organ which persisted for several weeks. Flow cytometric analysis of hepatic immune cell populations showed that HPD feeding induced activation of macrophages and neutrophils. Neutralization of the pro-inflammatory cytokine IL-1β or depletion of macrophages with clodronate-loaded liposomes or with genetic models did not ameliorate liver necrosis. In contrast, the depletion of neutrophils prevented HPD-induced hepatic inflammation. After prolonged feeding, HPD-feeding was associated with a strong increase of the cytokines IL-10 and IL-27, suggesting that anti-inflammatory mediators are activated to prevent nutrient-overload-induced damage to the liver. In summary, whereas our data indicates that most extreme diets do not have a major impact on the liver within two weeks, diets with a very high protein content may lead to severe, acute hepatic damage and should therefore be avoided.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMetabolites
Brojčani podacivol. 13, br. 2, 153
e-ISSN2218-1989
DOIhttps://doi.org/10.3390/metabo13020153
URN:NBNurn:nbn:hr:184:452625
Datum objave publikacije2023-01-19
ProjektŠifra: IP-2016-06-9306
Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Naziv (engleski): Immune mechanisms in development of inflammation and metabolic syndrome in obesity
Kratica: INFLAMETAB
Voditelj: Bojan Polić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-2016-06-8027
Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Naziv (engleski): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Kratica: T-MEMORY
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP
ProjektŠifra: IP-CORONA-2020-04-2045
Naziv (hrvatski): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Naziv (engleski): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Kratica: CORONAWAI
Voditelj: Felix Martinus Wensveen
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
URL dokumentahttps://www.mdpi.com/2218-1989/13/2/153
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-01-25 14:07:38