prikaz prve stranice dokumenta Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions
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Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions
Current Microbiology, 78 (2021); 1188-1201. https://doi.org/10.1007/s00284-021-02390-3
Čanadi Jurešić, Gordana; Ćurko-Cofek, Božena; Barbarić, Martina; Mumiši, Nermina; Blagović, Branka; Jamnik, Polona

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Čanadi Jurešić, G., Ćurko Cofek, B., Barbarić, M., Mumiši, N., Blagović, B. i Jamnik, P. (2021). Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions. Current Microbiology, 78., 1188-1201. doi: 10.1007/s00284-021-02390-3

Čanadi Jurešić, Gordana, et al. "Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions." Current Microbiology, vol. 78, 2021, str. 1188-1201. https://doi.org/10.1007/s00284-021-02390-3

Čanadi Jurešić, Gordana, Božena Ćurko Cofek, Martina Barbarić, Nermina Mumiši, Branka Blagović i Polona Jamnik. "Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions." Current Microbiology 78 (2021): 1188-1201. https://doi.org/10.1007/s00284-021-02390-3

Čanadi Jurešić, G., et al. (2021) 'Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions', Current Microbiology, 78, str. 1188-1201. doi: 10.1007/s00284-021-02390-3

Čanadi Jurešić G, Ćurko Cofek B, Barbarić M, Mumiši N, Blagović B, Jamnik P. Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions. Current Microbiology [Internet]. 2021. [pristupljeno 16.05.2024.];78:1188-1201. doi: 10.1007/s00284-021-02390-3

G. Čanadi Jurešić, B. Ćurko Cofek, M. Barbarić, N. Mumiši, B. Blagović i P. Jamnik, "Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions", Current Microbiology, vol. 78, str. 1188-1201, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:467796. [Citirano: 16.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:467796
Podaci o radu
Naslov (engleski)Response of Saccharomyces cerevisiae W303 to Iron and Lead Toxicity in Overloaded Conditions
AutorGordana Čanadi Jurešić
AutorBožena Ćurko-Cofek
AutorMartina Barbarić
AutorNermina Mumiši
AutorBranka Blagović
AutorPolona Jamnik
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Biologija
Znanstveno / umjetničko
područje, polje i grana		INTERDISCIPLINARNA PODRUČJA ZNANOSTI
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Interdisciplinarne biotehničke znanosti
Sažetak (engleski)
Yeast Saccharomyces cerevisiae is an ideal model organism for studying molecular mechanisms of the stress response provoked by metals. In this work, yeast cells response to iron (Fe3+) or lead (Pb2+) exposure was tested and compared. Survival test was used to determine testing doses of metal ions – for Fe3+ it was 4 mM and for Pb2+ 8mM. These (high, over-loaded) doses provoked comparable values of growth inhibition, but different values in vitality measurement. The percentage of metabolically active cells, determined by fluorescent FUN-1 dye, was lower in Pb2+ than in Fe3+ treated cells. Besides, endogenous antioxidant defence systems in the cells treated with Pb2+ were less efficient compared to Fe3+. At the mitochondrial level, the effects of metal ions were in correlation with the results of cell metabolic activity. The mitochondrial proteome of Pb2+ treated cells showed the domination of protein down- regulation. Yeast cells treated either with Fe3+ or Pb2+ shared 19 common significantly changed proteins. The affected proteins were involved in different cellular process and among them only five proteins belong to energy and carbohydrate metabolism, and protein biosynthesis. Based on all obtained results, it is possible to conclude that the effects of Fe3+ and Pb2+ on yeast cells show rather specific patterns of toxicity and stress response.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCurrent Microbiology
Brojčani podacivol. 78, str. 1188-1201
p-ISSN0343-8651
e-ISSN1432-0991
DOIhttps://doi.org/10.1007/s00284-021-02390-3
URN:NBNurn:nbn:hr:184:467796
Datum objave publikacije2021
URL dokumentahttp://bib.irb.hr/1104907
Vrsta resursaTekst
Prava pristupaInstitucijski pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-02-02 08:29:21