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Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction
Scandinavian Journal of Immunology, 74 (2011), 2; 195-204. https://doi.org/10.1111/j.1365-3083.2011.02554.x
Laškarin, Gordana; Peršić, Viktor; Ružić, Alen; Miletić, Bojan; Rakić, Marijana; Travica Samsa, Dijana; Raljević, Damir; Pejčinović Pehar, Vesna; Miškulin, Rajko; Rukavina, Daniel

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Laškarin, G., Peršić, V., Ružić, A., Miletić, B., Rakić, M., Travica Samsa, D. ... Rukavina, D. (2011). Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction. Scandinavian Journal of Immunology, 74. (2), 195-204. doi: 10.1111/j.1365-3083.2011.02554.x

Laškarin, Gordana, et al. "Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction." Scandinavian Journal of Immunology, vol. 74, br. 2, 2011, str. 195-204. https://doi.org/10.1111/j.1365-3083.2011.02554.x

Laškarin, Gordana, Viktor Peršić, Alen Ružić, Bojan Miletić, Marijana Rakić, Dijana Travica Samsa, Damir Raljević, Vesna Pejčinović Pehar, Rajko Miškulin i Daniel Rukavina. "Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction." Scandinavian Journal of Immunology 74, br. 2 (2011): 195-204. https://doi.org/10.1111/j.1365-3083.2011.02554.x

Laškarin, G., et al. (2011) 'Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction', Scandinavian Journal of Immunology, 74(2), str. 195-204. doi: 10.1111/j.1365-3083.2011.02554.x

Laškarin G, Peršić V, Ružić A, Miletić B, Rakić M, Travica Samsa D, i sur.. Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction. Scandinavian Journal of Immunology [Internet]. 2011. [pristupljeno 26.04.2024.];74(2):195-204. doi: 10.1111/j.1365-3083.2011.02554.x

G. Laškarin, et al., "Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction", Scandinavian Journal of Immunology, vol. 74, br. 2, str. 195-204, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:027474. [Citirano: 26.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:027474
Podaci o radu
Naslov (engleski)Perforin-Mediated Cytotoxicity in non-ST Elevation Myocardial Infarction
AutorGordana Laškarin
AutorViktor Peršić
AutorAlen Ružić
AutorBojan Miletić
AutorMarijana Rakić
AutorDijana Travica Samsa
AutorDamir Raljević
AutorVesna Pejčinović Pehar
AutorRajko Miškulin
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
The aim of this investigation was to examine the role of perforin (P)-mediated cytotoxicity in the dynamics of tissue damage in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drugs. We enrolled 48 patients with NSTEMI in this study [age, 71.5 years ; 61.5/76 (median, 25th/75th percentiles)]. The percentage of total peripheral blood P(+) lymphocytes was elevated owing to the increased frequency of P(+) cells within natural killer (NK) subsets, T and NKT cells in patients on day 1 after NSTEMI when compared with healthy controls. Positive correlations were found between cardiac troponin I plasma concentrations and the frequency of P(+) cells, P(+) T cells, P(+) NK cells and their CD56(+dim) and CD56(+bright) subsets during the first week after the NSTEMI. The expression of P in NK cells was accompanied by P-mediated cytotoxicity against K-562 targets at all days examined, except day 21, when an anti-perforin monoclonal antibody did not completely abolish the killing. The percentage of P(+) T cells, P(+) NKT cells and P(+) NK subsets was the highest on the day 1 after NSTEMI and decreased in the post- infarction period. CD56(+) lymphocytes were found in damaged myocardium, suggesting their tissue recruitment. In conclusion, patients with NSTEMI have a strong and prolonged P- mediated systemic inflammatory reaction, which may sustain autoaggressive reactions towards myocardial tissue during the development of myocardial infarction.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScandinavian Journal of Immunology
Brojčani podacivol. 74, br. 2, str. 195-204
p-ISSN0300-9475
DOIhttps://doi.org/10.1111/j.1365-3083.2011.02554.x
URN:NBNurn:nbn:hr:184:027474
Datum objave publikacije2011
URL dokumentahttp://bib.irb.hr/1058644
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-04-11 10:26:09