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Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
Biomedicines, 11 (2023), 10; 2793. https://doi.org/10.3390/biomedicines11102793
De Marchi, Fabiola; Munitić, Ivana; Vidatić, Lea; Papić, Eliša; Rački, Valentino; Nimac, Jerneja; Jurak, Igor; Novotni, Gabriela; Rogelj, Boris; Vuletić, Vladimira; Lisčić, Rajka M.; Cannon, Jason R.; Buratti, Emanuele; Mazzini, Letizia; Hećimović, Silva Više autora...

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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De Marchi, F., Munitić, I., Vidatić, L., Papić, E., Rački, V., Nimac, J. ... Hećimović, S. (2023). Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders. Biomedicines, 11. (10). doi: 10.3390/biomedicines11102793

De Marchi, Fabiola, et al. "Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders." Biomedicines, vol. 11, br. 10, 2023. https://doi.org/10.3390/biomedicines11102793

De Marchi, Fabiola, Ivana Munitić, Lea Vidatić, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, et al. "Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders." Biomedicines 11, br. 10 (2023). https://doi.org/10.3390/biomedicines11102793

De Marchi, F., et al. (2023) 'Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders', Biomedicines, 11(10). doi: 10.3390/biomedicines11102793

De Marchi F, Munitić I, Vidatić L, Papić E, Rački V, Nimac J, i sur.. Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders. Biomedicines [Internet]. 14.10.2023. [pristupljeno 03.05.2024.];11(10). doi: 10.3390/biomedicines11102793

F. De Marchi, et al., "Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders", Biomedicines, vol. 11, br. 10, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:744547. [Citirano: 03.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:744547
Podaci o radu
Naslov (engleski)Overlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders
AutorFabiola De Marchi
AutorIvana Munitić
AutorLea Vidatić
AutorEliša Papić
AutorValentino Rački
AutorJerneja Nimac
AutorIgor Jurak
AutorGabriela Novotni
AutorBoris Rogelj
AutorVladimira Vuletić
AutorRajka M. Lisčić
AutorJason R. Cannon
AutorEmanuele Buratti
AutorLetizia Mazzini
AutorSilva Hećimović
Autorova ustanova(Klinički bolnički centar Rijeka)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za neurologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as well as in a seemingly distinct Niemann–Pick type C disease with primarily juvenile onset. This strongly argues for an overlap in pathogenic mechanisms. The commonly researched immune targets include various immune cell subsets, such as microglia, peripheral macrophages, and regulatory T cells (Tregs); the complement system; and other soluble factors. In this review, we compare these neurodegenerative diseases from a clinical point of view and highlight common pathways and mechanisms of protein aggregation, neurodegeneration, and/or neuroinflammation that could potentially lead to shared treatment strategies for overlapping immune dysfunctions in these diseases. These approaches include but are not limited to immunisation, complement cascade blockade, microbiome regulation, inhibition of signal transduction, Treg boosting, and stem cell transplantation.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 11, br. 10, 2793
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11102793
URN:NBNurn:nbn:hr:184:744547
Datum objave publikacije2023-10-14
URL dokumentahttps://www.mdpi.com/2227-9059/11/10/2793
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-10-18 10:03:49