prikaz prve stranice dokumenta Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both
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Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both
Scientific Reports, 13 (2023), 1; 21390. https://doi.org/10.1038/s41598-023-48397-7
Beitari, Saina; Agbayani, Gerard; Hewitt, Melissa; Duque, Diana; Bavananthasivam, Jegarubee; Sandhu, Jagdeep K.; Akache, Bassel; Hadžisejdić, Ita; Tran, Anh

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Beitari, S., Agbayani, G., Hewitt, M., Duque, D., Bavananthasivam, J., Sandhu, J. K. ... Tran, A. (2023). Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both. Scientific Reports, 13. (1). doi: 10.1038/s41598-023-48397-7

Beitari, Saina, et al. "Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both." Scientific Reports, vol. 13, br. 1, 2023. https://doi.org/10.1038/s41598-023-48397-7

Beitari, Saina, Gerard Agbayani, Melissa Hewitt, Diana Duque, Jegarubee Bavananthasivam, Jagdeep K. Sandhu, Bassel Akache, Ita Hadžisejdić i Anh Tran. "Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both." Scientific Reports 13, br. 1 (2023). https://doi.org/10.1038/s41598-023-48397-7

Beitari, S., et al. (2023) 'Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both', Scientific Reports, 13(1). doi: 10.1038/s41598-023-48397-7

Beitari S, Agbayani G, Hewitt M, Duque D, Bavananthasivam J, Sandhu JK, i sur.. Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both. Scientific Reports [Internet]. 04.12.2023. [pristupljeno 02.05.2024.];13(1). doi: 10.1038/s41598-023-48397-7

S. Beitari, et al., "Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both", Scientific Reports, vol. 13, br. 1, Prosinac 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:514775. [Citirano: 02.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:514775
Podaci o radu
Naslov (engleski)Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both
AutorSaina Beitari
AutorGerard Agbayani
AutorMelissa Hewitt
AutorDiana Duque
AutorJegarubee Bavananthasivam
AutorJagdeep K. Sandhu
AutorBassel Akache
AutorIta Hadžisejdić
AutorAnh Tran
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Abstract A critical feature of the VSV vector platform is the ability to pseudotype the virus with different glycoproteins from other viruses, thus altering cellular tropism of the recombinant virus. The route of administration is critical in triggering local and systemic immune response and protection. Most of the vaccine platforms used at the forefront are administered by intramuscular injection. However, it is not known at what level ACE2 is expressed on the surface of skeletal muscle cells, which will have a significant impact on the efficiency of a VSV-SARS-CoV-2 spike vaccine to mount a protective immune response when administered intramuscularly. In this study, we investigate the immunogenicity and efficacy of a prime-boost immunization regimen administered intranasally (IN), intramuscularly (IM), or combinations of the two. We determined that the prime-boost combinations of IM followed by IN immunization (IM + IN) or IN followed by IN immunization (IN + IN) exhibited strong spike-specific IgG, IgA and T cell response in vaccinated K18 knock-in mice. Hamsters vaccinated with two doses of VSV expressing SARS-CoV-2 spike, both delivered by IN or IM + IN, showed strong protection against SARS-CoV-2 variants of concern Alpha and Delta. This protection was also observed in aged hamsters. Our study underscores the highly crucial role immunization routes have with the VSV vector platform to elicit a strong and protective immune response.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 13, br. 1, 21390
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-023-48397-7
URN:NBNurn:nbn:hr:184:514775
Datum objave publikacije2023-12-04
URL dokumentahttps://www.nature.com/articles/s41598-023-48397-7
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-12-19 08:49:12