prikaz prve stranice dokumenta The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
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The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
Cell Death Discovery, 10 (2024), 1; 98. https://doi.org/10.1038/s41420-024-01872-0
Suman, Iva; Šimić, Lidija; Čanadi Jurešić, Gordana; Buljević, Sunčica; Klepac, Damir; Domitrović, Robert

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Suman, I., Šimić, L., Čanadi Jurešić, G., Buljević, S., Klepac, D. i Domitrović, R. (2024). The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway. Cell Death Discovery, 10. (1). doi: 10.1038/s41420-024-01872-0

Suman, Iva, et al. "The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway." Cell Death Discovery, vol. 10, br. 1, 2024. https://doi.org/10.1038/s41420-024-01872-0

Suman, Iva, Lidija Šimić, Gordana Čanadi Jurešić, Sunčica Buljević, Damir Klepac i Robert Domitrović. "The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway." Cell Death Discovery 10, br. 1 (2024). https://doi.org/10.1038/s41420-024-01872-0

Suman, I., et al. (2024) 'The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway', Cell Death Discovery, 10(1). doi: 10.1038/s41420-024-01872-0

Suman I, Šimić L, Čanadi Jurešić G, Buljević S, Klepac D, Domitrović R. The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway. Cell Death Discovery [Internet]. 24.02.2024. [pristupljeno 07.11.2024.];10(1). doi: 10.1038/s41420-024-01872-0

I. Suman, L. Šimić, G. Čanadi Jurešić, S. Buljević, D. Klepac i R. Domitrović, "The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway", Cell Death Discovery, vol. 10, br. 1, Veljača 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:490711. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:490711
Podaci o radu
Naslov (engleski)The interplay of mitophagy, autophagy, and apoptosis in cisplatin-induced kidney injury: involvement of ERK signaling pathway
AutorIva Suman
AutorLidija Šimić
AutorGordana Čanadi Jurešić
AutorSunčica Buljević
AutorDamir Klepac
AutorRobert Domitrović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
AKI induced by CP chemotherapy remains an obstacle during patient treatments. Extracellular signal-regulated protein kinases 1/2 (ERK), key participants in CP-induced nephrotoxicity, are suggested to be involved in the regulation of mitophagy, autophagy, and apoptosis. Human renal proximal tubular cells (HK-2) and BALB/cN mice were used to determine the role of ERK in CP-induced AKI. We found that active ERK is involved in cell viability reduction during apoptotic events but exerts a protective role in the early stages of treatment. Activation of ERK acts as a maintainer of the mitochondrial population and is implicated in mitophagy initiation but has no significant role in its conduction. In the late stages of CP treatment when ATP is deprived, general autophagy that requires ERK activation is initiated as a response, in addition to apoptosis activation. Furthermore, activation of ERK is responsible for the decrease in reserve respiratory capacity and controls glycolysis regulation during CP treatment. Additionally, we found that ERK activation is also required for the induction of NOXA gene and protein expression as well as FoxO3a nuclear translocation, but not for the regular ERK-induced phosphorylation of FoxO3a on Ser294. In summary, this study gives detailed insight into the involvement of ERK activation and its impact on key cellular processes at different time points during CP-induced kidney injury. Inhibitors of ERK activation, including Mirdametinib, are important in the development of new therapeutic strategies for the treatment of AKI in patients receiving CP chemotherapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCell Death Discovery
Brojčani podacivol. 10, br. 1, 98
e-ISSN2058-7716
DOIhttps://doi.org/10.1038/s41420-024-01872-0
URN:NBNurn:nbn:hr:184:490711
Datum objave publikacije2024-02-24
ProjektŠifra: uniri-mladi-biomed-20-17
Naziv (hrvatski): Modulacija MEK-ERK MAPK signalnog puta u CP-induciranoj mitofagiji u bubrezima
Naziv (engleski): Modulation of MEK-ERK MAPK signalling pathway in CP-induced mitophagy in kidneys
Voditelj: Iva Potočnjak
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Sveučilište u Rijeci
ProjektŠifra: uniri-biomed-18-30
Naziv (hrvatski): Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta
Naziv (engleski): Interaction between drugs and phytochemicals: the role of FOXO signaling pathway
Voditelj: Robert Domitrović
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
ProjektŠifra: uniri-prirod-18-299
Naziv (hrvatski): Sinteza i karakterizacija pametnih polimernih nanočestica s nitroksidnim radikalima
Naziv (engleski): Synthesis and characterization of smart polymer nanoparticles with nitroxide radicals
Voditelj: Damir Klepac
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
URL dokumentahttps://www.nature.com/articles/s41420-024-01872-0
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-02-28 08:15:52