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Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience
Acta Medica Academica, 52 (2024), 3; 161-168. https://doi.org/10.5644/ama2006-124.430
Đordević, Ana; Grahovac, Blaženka; Šegulja, Silvije; Bilić Zulle, Lidija; Roganović, Jelena

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Đordević, A., Grahovac, B., Šegulja, S., Bilić Zulle, L. i Roganović, J. (2024). Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience. Acta Medica Academica, 52. (3), 161-168. doi: 10.5644/ama2006-124.430

Đordević, Ana, et al. "Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience." Acta Medica Academica, vol. 52, br. 3, 2024, str. 161-168. https://doi.org/10.5644/ama2006-124.430

Đordević, Ana, Blaženka Grahovac, Silvije Šegulja, Lidija Bilić Zulle i Jelena Roganović. "Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience." Acta Medica Academica 52, br. 3 (2024): 161-168. https://doi.org/10.5644/ama2006-124.430

Đordević, A., et al. (2024) 'Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience', Acta Medica Academica, 52(3), str. 161-168. doi: 10.5644/ama2006-124.430

Đordević A, Grahovac B, Šegulja S, Bilić Zulle L, Roganović J. Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience. Acta Medica Academica [Internet]. 23.02.2024. [pristupljeno 23.11.2024.];52(3):161-168. doi: 10.5644/ama2006-124.430

A. Đordević, B. Grahovac, S. Šegulja, L. Bilić Zulle i J. Roganović, "Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience", Acta Medica Academica, vol. 52, br. 3, str. 161-168, Veljača 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:548063. [Citirano: 23.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:548063
Podaci o radu
Naslov (engleski)Inherited Thrombophilia and Risk of Thrombosis in Children with Cancer: a Single-center Experience
AutorAna Đordević
AutorBlaženka Grahovac
AutorSilvije Šegulja
AutorLidija Bilić Zulle
AutorJelena Roganović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za onkologiju i radioterapiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za pedijatriju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička biokemija
Sažetak (engleski)
Objectives. Thrombosis is an increasingly recognized complication of childhood malignancy and its treatment. The incidence and etiology of pediatric cancer-related thrombosis is still not well understood. The aim of this study was to evaluate the preva- lence of common prothrombotic genetic conditions in children with cancer, the frequency of thrombosis, and the role of inher- ited thrombophilia in the development of thrombosis in a pediatric oncology population. Patients and Methods. Forty-seven children (36 treated for hematological malignancies and 11 for solid tumors) with a median age of 8.8. years (range 0.4 – 19.3 years) were included in the study. Genetic polymorphisms of Factor V Leiden (G1691A), prothrombin G20210A, and methy- lenetetrahydrofolate reductase (MTHFR) C677T were determined by real-time polymerase chain reaction-based DNA analysis. Results. Four (8.5%) patients were heterozygous for Factor V Leiden, 3 (6.4%) were heterozygous for prothrombin G20210A mutation, and 3 (6.4%) were homozygous for MTHFR C677T mutation. All patients had implanted central venous catheters. Four (8.5%) children had documented thrombosis, three of which were in the upper venous system. Two of the four patients with thrombosis had Factor V Leiden heterozygosity. Conclusions. Thrombosis is an important complication of childhood cancer. The risk of thrombosis may be increased in patients with Factor V Leiden. In the absence of consensus guidelines, our results support the recommendation for thrombophilia screening in children with cancer.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Medica Academica
Brojčani podacivol. 52, br. 3, str. 161-168
p-ISSN1840-1848
e-ISSN1840-2879
DOIhttps://doi.org/10.5644/ama2006-124.430
URN:NBNurn:nbn:hr:184:548063
Datum objave publikacije2024-02-23
URL dokumentahttps://www.ama.ba/index.php/ama/article/view/551
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2024-03-07 10:38:15