prikaz prve stranice dokumenta Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment
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Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment
Crystals, 14 (2024), 12; 1073. https://doi.org/10.3390/cryst14121073
Štefan, Leo; Đilović, Ivica; Saftić Martinović, Lara; Vianello, Robert; Čikoš, Ana

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Štefan, L., Đilović, I., Saftić Martinović, L., Vianello, R. i Čikoš, A. (2024). Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment. Crystals, 14. (12). doi: 10.3390/cryst14121073

Štefan, Leo, et al. "Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment." Crystals, vol. 14, br. 12, 2024. https://doi.org/10.3390/cryst14121073

Štefan, Leo, Ivica Đilović, Lara Saftić Martinović, Robert Vianello i Ana Čikoš. "Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment." Crystals 14, br. 12 (2024). https://doi.org/10.3390/cryst14121073

Štefan, L., et al. (2024) 'Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment', Crystals, 14(12). doi: 10.3390/cryst14121073

Štefan L, Đilović I, Saftić Martinović L, Vianello R, Čikoš A. Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment. Crystals [Internet]. 12.12.2024. [pristupljeno 23.12.2024.];14(12). doi: 10.3390/cryst14121073

L. Štefan, I. Đilović, L. Saftić Martinović, R. Vianello i A. Čikoš, "Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment", Crystals, vol. 14, br. 12, Prosinac 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:050383. [Citirano: 23.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:050383
Podaci o radu
Naslov (engleski)Methimazole-Related Substances: Structural Characterization and In Silico Toxicity Assessment
AutorLeo Štefan
AutorIvica Đilović
AutorLara Saftić Martinović
AutorRobert Vianello
AutorAna Čikoš
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
The continuous tightening of pharmaceutical regulations forces drug manufacturers to unambiguously characterize the substances related to the active pharmaceutical ingredients (API). Here, we report the synthesis, complete spectroscopic, chromatographic, thermal and computational characterization, as well as in silico prediction of bacterial mutagenicity for two previously reported but never fully characterized impurities of methimazole. Additionally, their structures were analyzed by single-crystal X-ray diffraction. 1-Methyl-(2-methylthio)-1H-imidazole also known as methimazole impurity C, was obtained mainly in the form of the iodide salt (C5H9IN2S) crystallizing in monoclinic space group P21/c. The disulfide (2,2′-disulphanylbis(1-methyl-1H-imidazole)), C8H10N4S2) was obtained in yellow form crystallizing in the monoclinic C2/c space group.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCrystals
Brojčani podacivol. 14, br. 12, 1073
e-ISSN2073-4352
DOIhttps://doi.org/10.3390/cryst14121073
URN:NBNurn:nbn:hr:184:050383
Datum objave publikacije2024-12-12
URL dokumentahttps://www.mdpi.com/2073-4352/14/12/1073
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-17 07:29:16