The treatment of severe asthma differs from the treatment of other types of asthma due to the complexity and severity of symptoms and the need for specific therapeutic approaches. Severe asthma often requires a combination of different therapies to achieve symptom control and improve the quality of life. The cornerstone of severe asthma treatment is the use of high doses of inhaled corticosteroids (ICS) in combination with long-acting beta2-agonists (LABA), a combination that acts anti-inflammatory. If the basic therapy is not sufficient, other drugs such as anticholinergics or leukotriene modifiers, which help control inflammation, are added. Biologic drugs represent a significant advancement in the treatment of severe asthma. They target specific molecules in the immune system responsible for inflammation and bronchospasm. In addition to pharmacological treatment, it is important to avoid triggers that can worsen asthma (identification and avoidance of allergens, smoking cessation). Patient education on the proper use of inhalers and monitoring symptoms is crucial for the successful management of severe asthma. Unlike milder forms of asthma, severe asthma also requires referral to specialist departments, where patients receive a comprehensive assessment and personalized treatment plan. Regular check-ups and adjustments to therapy based on the patient's response are essential for achieving optimal disease control. Treating severe asthma requires a multidisciplinary approach and continuous collaboration between the patient and healthcare providers to reduce the frequency of exacerbations and improve quality of life.