prikaz prve stranice dokumenta Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
  Preuzmi
PDF 3.91 MB
Znanstveni rad - Izvorni znanstveni rad
Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
Cells, 12 (2023), 14; 1841. https://doi.org/10.3390/cells12141841
Krasić, Jure; Škara Abramović, Lucija; Himelreich Perić, Marta; Vanjorek, Vedran; Gangur, Marko; Zovko, Dragana; Malnar, Marina; Mašić, Silvija; Demirović, Alma; Jurić, Bernardica; Ulamec, Monika; Ćorić, Marijana; Ježek, Davor; Kuliš, Tomislav; Sinčić, Nino Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Krasić, J., Škara Abramović, L., Himelreich Perić, M., Vanjorek, V., Gangur, M., Zovko, D. ... Sinčić, N. (2023). Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry. Cells, 12. (14). doi: 10.3390/cells12141841

Krasić, Jure, et al. "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry." Cells, vol. 12, br. 14, 2023. https://doi.org/10.3390/cells12141841

Krasić, Jure, Lucija Škara Abramović, Marta Himelreich Perić, Vedran Vanjorek, Marko Gangur, Dragana Zovko, Marina Malnar, et al. "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry." Cells 12, br. 14 (2023). https://doi.org/10.3390/cells12141841

Krasić, J., et al. (2023) 'Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry', Cells, 12(14). doi: 10.3390/cells12141841

Krasić J, Škara Abramović L, Himelreich Perić M, Vanjorek V, Gangur M, Zovko D, i sur.. Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry. Cells [Internet]. 13.07.2023. [pristupljeno 28.12.2024.];12(14). doi: 10.3390/cells12141841

J. Krasić, et al., "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry", Cells, vol. 12, br. 14, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:014734. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:014734
Podaci o radu
Naslov (engleski)Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
AutorJure Krasić
AutorLucija Škara Abramović
AutorMarta Himelreich Perić
AutorVedran Vanjorek
AutorMarko Gangur
AutorDragana Zovko
AutorMarina Malnar
AutorSilvija Mašić
AutorAlma Demirović
AutorBernardica Jurić
AutorMonika Ulamec
AutorMarijana Ćorić
AutorDavor Ježek
AutorTomislav Kuliš
AutorNino Sinčić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA UROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
The accurate management of testicular germ cell tumors (TGCTs) depends on identifying the individual histological tumor components. Currently available data on protein expression in TGCTs are limited. The human protein atlas (HPA) is a comprehensive resource presenting the expression and localization of proteins across tissue types and diseases. In this study, we have compared the data from the HPA with our in-house immunohistochemistry on core TGCT diagnostic genes to test reliability and potential biomarker genes. We have compared the protein expression of 15 genes in TGCT patients and non-neoplastic testicles with the data from the HPA. Protein expression was converted into diagnostic positivity. Our study discovered discrepancies in three of the six core TGCT diagnostic genes, POU5F1, KIT and SOX17 in HPA. DPPA3, CALCA and TDGF1 were presented as potential novel TGCT biomarkers. MGMT was confirmed while RASSF1 and PRSS21 were identified as biomarkers of healthy testicular tissue. Finally, SALL4, SOX17, RASSF1 and PRSS21 dysregulation in the surrounding testicular tissue with complete preserved spermatogenesis of TGCT patients was detected, a potential early sign of neoplastic transformation. We highlight the importance of a multidisciplinary collaborative approach to fully understand the protein landscape of human testis and its pathologies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 12, br. 14, 1841
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells12141841
URN:NBNurn:nbn:hr:105:014734
Datum objave publikacije2023-07-13
ProjektŠifra: KK.01.1.1.01.0008
Naziv (hrvatski): Reproduktivna i regenerativna medicina - istraživanja novih platformi i potencijala
Naziv (engleski): Scientific Center of Excellence for Reproductive and Regenerative Medicine
Kratica: CERRM
Voditelj: Davor Ježek
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.mdpi.com/2073-4409/12/14/1841
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-05 08:07:35