The properties of ultrasound, a known medical tool, allow the use of sound waves with high frequencies to penetrate the body and interpret tissue properties based on their densities. Ultrasound is used in clinical medicine because of its benefits, but is also widely used in several interventional procedures, and is known as interventional ultrasound. In those procedures, ultrasound serves as the eyes of the operator, and by that, interventional ultrasound decreases complications as well as makes the procedure quicker and safer. This paper presents a comprehensive overview, beginning with the general physical properties of ultrasound that help recognize normal and pathological anatomical structure and what is interventional radiology. Then, be discussed the comprehensive use of interventional ultrasound in the field of medicine. Those will include the indications, steps in the process, and complications of several interventional procedures, with emphasis on the importance of ultrasound in guidance of those techniques. Some key applications of interventional ultrasound include vascular access and vascular procedures, biopsies, and injections. Those interventions will be discussed for different body systems with organs with emphasis on how the use of ultrasound is significant for those procedures to be more successful. In addition, some limitations will be mentioned, and their solutions in the developing field of interventional ultrasound. Those include the approach to improving the clinical skills of the operator, the anatomical barriers of the patient, and the technological aspect of ultrasound in the future of clinical and interventional medicine.