prikaz prve stranice dokumenta Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center
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Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center
Diagnostics, 14 (2024), 6; 623. https://doi.org/10.3390/diagnostics14060623
Leniček Krleža, Jasna; Katušić Bojanac, Ana; Jakovljević, Gordana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Leniček Krleža, J., Katušić Bojanac, A. i Jakovljević, G. (2024). Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center. Diagnostics, 14. (6). doi: 10.3390/diagnostics14060623

Leniček Krleža, Jasna, et al. "Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center." Diagnostics, vol. 14, br. 6, 2024. https://doi.org/10.3390/diagnostics14060623

Leniček Krleža, Jasna, Ana Katušić Bojanac i Gordana Jakovljević. "Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center." Diagnostics 14, br. 6 (2024). https://doi.org/10.3390/diagnostics14060623

Leniček Krleža, J., Katušić Bojanac, A. i Jakovljević, G. (2024) 'Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center', Diagnostics, 14(6). doi: 10.3390/diagnostics14060623

Leniček Krleža J, Katušić Bojanac A, Jakovljević G. Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center. Diagnostics [Internet]. 15.03.2024. [pristupljeno 09.11.2024.];14(6). doi: 10.3390/diagnostics14060623

J. Leniček Krleža, A. Katušić Bojanac i G. Jakovljević, "Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center", Diagnostics, vol. 14, br. 6, Ožujak 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:081071. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:081071
Podaci o radu
Naslov (engleski)Determination of l-Asparaginase Activity and Its Therapeutic Monitoring in Children with Hematological Malignancies in a Single Croatian Center
AutorJasna Leniček Krleža
AutorAna Katušić Bojanac
AutorGordana Jakovljević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU BIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: Among malignant diseases which develop during childhood, hematological cancers, such as leukemias and lymphomas, are the most common. Outcomes have greatly improved due to the refinement of multiagent chemotherapy regimens that include enhanced asparaginase therapy. In this study, we aimed to evaluate our experiences related to the analytical and clinical significance of determining l-Asparaginase activity. Methods: Since 2016, the Laboratory of the Children’s Hospital Zagreb has routinely measured l-Asparaginase activity and to date, has measured more than 280 examples of activity in a total of 57 children with hematological malignancy treated at the Pediatric Oncology Department of the Children’s Hospital Zagreb. Three asparaginase products were available: native E. colil-Asparaginase; a pegylated form of this enzyme; and a native product from Erwinia chrysanthemi. A retrospective data analysis was performed. Results: Out of the fifty-seven children, seven had an allergic reaction (12.3%), five (8.8%) had silent inactivation, and seven (12.3%) developed acute pancreatitis. Allergic reactions and silent inactivation were more common in children treated with native E. colil-Asparaginase, while pancreatitis was more common in children treated with the pegylated form. Conclusions: The monitoring of l-Asparaginase activity may help to optimize therapy by identifying patients with ‘silent inactivation’, and/or by dose correction when l-Asparaginase activity is too high (slow elimination).
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiagnostics
Brojčani podacivol. 14, br. 6, 623
e-ISSN2075-4418
DOIhttps://doi.org/10.3390/diagnostics14060623
URN:NBNurn:nbn:hr:105:081071
Datum objave publikacije2024-03-15
URL dokumentahttps://www.mdpi.com/2075-4418/14/6/623
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-10-22 09:37:24