prikaz prve stranice dokumenta Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections
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Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections
Microorganisms, 12 (2024), 4; 657. https://doi.org/10.3390/microorganisms12040657
Židovec-Lepej, Snježana; Bodulić, Kristian; Bogdanić, Maja; Gorenec, Lana; Savić, Vladimir; Grgić, Ivana; Sabadi, Dario; Santini, Marija; Radmanić Matotek, Leona; Kučinar, Jasmina; Barbić, Ljubo; Žmak, Ljiljana; Ferenc, Thomas; Stevanović, Vladimir; Antolašić, Ljiljana; Milašinčić, Ljiljana; Hruškar, Željka; Vujica Ferenc, Mateja; Vilibić-Čavlek, Tatjana Više autora...

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Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Židovec Lepej, S., Bodulić, K., Bogdanić, M., Gorenec, L., Savić, V., Grgić, I. ... Vilibić Čavlek, T. (2024). Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections. Microorganisms, 12. (4). doi: 10.3390/microorganisms12040657

Židovec Lepej, Snježana, et al. "Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections." Microorganisms, vol. 12, br. 4, 2024. https://doi.org/10.3390/microorganisms12040657

Židovec Lepej, Snježana, Kristian Bodulić, Maja Bogdanić, Lana Gorenec, Vladimir Savić, Ivana Grgić, Dario Sabadi, et al. "Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections." Microorganisms 12, br. 4 (2024). https://doi.org/10.3390/microorganisms12040657

Židovec Lepej, S., et al. (2024) 'Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections', Microorganisms, 12(4). doi: 10.3390/microorganisms12040657

Židovec Lepej S, Bodulić K, Bogdanić M, Gorenec L, Savić V, Grgić I, i sur.. Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections. Microorganisms [Internet]. 26.03.2024. [pristupljeno 05.04.2025.];12(4). doi: 10.3390/microorganisms12040657

S. Židovec Lepej, et al., "Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections", Microorganisms, vol. 12, br. 4, Ožujak 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:949994. [Citirano: 05.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:949994
Podaci o radu
Naslov (engleski)Proinflammatory Chemokine Levels in Cerebrospinal Fluid of Patients with Neuroinvasive Flavivirus Infections
AutorSnježana Židovec-Lepej
AutorKristian Bodulić
AutorMaja Bogdanić
AutorLana Gorenec
AutorVladimir Savić
AutorIvana Grgić
AutorDario Sabadi
AutorMarija Santini
AutorLeona Radmanić Matotek
AutorJasmina Kučinar
AutorLjubo Barbić
AutorLjiljana Žmak
AutorThomas Ferenc
AutorVladimir Stevanović
AutorLjiljana Antolašić
AutorLjiljana Milašinčić
AutorŽeljka Hruškar
AutorMateja Vujica Ferenc
AutorTatjana Vilibić-Čavlek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Tick-borne encephalitis virus (TBEV) and West Nile virus (WNV) are the most important neuroinvasive arboviruses detected in Europe. In this study, we analyzed cerebrospinal fluid (CSF) concentrations of 12 proinflammatory chemokines (CCL2, CCL3, CCL4, CCL11, CCL17, CCL20, CXCL1, CXCL5, CXCL8, CXCL9, CXCL10, and CXCL11) in 77 patients with neuroinvasive diseases (NIDs). Flavivirus infection was confirmed in 62 patients (TBEV and WNV in 31 patients each), while in 15 patients the etiology of NID... Više was not determined (NDE). Similar patterns of high-level expression of chemokines regulating monocyte/macrophage responses (CCL2), neutrophil recruitment (CXCL1 and CXCL8), and interferon-inducible chemoattractants for leukocytes (CXCL10 and CXCL11) have been observed in WNV and TBEV groups. None of the tested chemokines significantly differed between patients with TBEV or WNV. Concentrations of CCL17, CCL20, CXCL5, CXCL10, and CXCL11 were significantly lower in both WNV and TBEV groups compared to NID NDE patients. The logistic regression model showed that CSF concentrations of CXCL11, CXCL5, and CXCL10 could potentially be used for the classification of patients into the WNV or TBEV group versus groups with other NIDs. This study identified, for the first time, similar patterns of CSF chemokine expression in WNV and TBEV infections, suggesting common immunopathogenic mechanisms in neuroinvasive flavivirus infections that should be further evaluated. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMicroorganisms
Brojčani podacivol. 12, br. 4, 657
e-ISSN2076-2607
DOIhttps://doi.org/10.3390/microorganisms12040657
URN:NBNurn:nbn:hr:105:949994
Datum objave publikacije2024-03-26
URL dokumentahttps://www.mdpi.com/2076-2607/12/4/657
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-02-28 08:31:11
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