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Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans
International Journal of Molecular Sciences, 25 (2024), 17; 9648. https://doi.org/10.3390/ijms25179648
Mirošević, Vid; Svaguša, Tomo; Matić, Natalija; Maldini, Krešimir; Šiljeg, Mario; Miličić, Davor; Gašparović, Hrvoje; Rudež, Igor; Šepac, Ana; Gojmerac, Lucija; Kulić, Ana; Baković, Petra; Sedlicć, Filip

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Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Mirošević, V., Svaguša, T., Matić, N., Maldini, K., Šiljeg, M., Miličić, D. ... Sedlicć, F. (2024). Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans. International Journal of Molecular Sciences, 25. (17). doi: 10.3390/ijms25179648

Mirošević, Vid, et al. "Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans." International Journal of Molecular Sciences, vol. 25, br. 17, 2024. https://doi.org/10.3390/ijms25179648

Mirošević, Vid, Tomo Svaguša, Natalija Matić, Krešimir Maldini, Mario Šiljeg, Davor Miličić, Hrvoje Gašparović, et al. "Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans." International Journal of Molecular Sciences 25, br. 17 (2024). https://doi.org/10.3390/ijms25179648

Mirošević, V., et al. (2024) 'Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans', International Journal of Molecular Sciences, 25(17). doi: 10.3390/ijms25179648

Mirošević V, Svaguša T, Matić N, Maldini K, Šiljeg M, Miličić D, i sur.. Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans. International Journal of Molecular Sciences [Internet]. 06.09.2024. [pristupljeno 01.04.2025.];25(17). doi: 10.3390/ijms25179648

V. Mirošević, et al., "Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans", International Journal of Molecular Sciences, vol. 25, br. 17, Rujan 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:934941. [Citirano: 01.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:934941
Podaci o radu
Naslov (engleski)Cardiotoxicity of Iron and Zinc and Their Association with the Mitochondrial Unfolded Protein Response in Humans
AutorVid Mirošević
AutorTomo Svaguša
AutorNatalija Matić
AutorKrešimir Maldini
AutorMario Šiljeg
AutorDavor Miličić
AutorHrvoje Gašparović
AutorIgor Rudež
AutorAna Šepac
AutorLucija Gojmerac
AutorAna Kulić
AutorPetra Baković
AutorFilip Sedlicć
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOFIZIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patofiziologija
Sažetak (engleski)
This study was designed to examine the association between myocardial concentrations of the trace elements Cu, Fe, Mn, Mo, and Zn and the expression of mitochondrial unfolded protein response (UPRmt) elements and the age of patients who received heart transplantation or a left-ventricular assist device (ageHTx/LVAD). Inductively coupled plasma mass spectrometry was used to determine the concentration of Cu, Fe, Mn, Mo, and Zn in the myocardium of control subjects and patients undergoing heart... Više transplantation or left-ventricular assist device (LVAD) implantation. We used ELISA to quantify the expression of UPRmt proteins and 4-Hydroxynonenal (4-HNE), which served as a marker of oxidative-stress-induced lipid peroxidation. Concentrations of Cu, Mn, Mo, and Zn were similar in the control and heart failure (HF) myocardium, while Fe showed a significant decrease in the HF group compared to the control. A higher cumulative concentration of Fe and Zn in the myocardium was associated with reduced ageHTx/LVAD, which was not observed for other combinations of trace elements or their individual effects. The trace elements Cu, Mn, and Zn showed positive correlations with several UPRmt proteins, while Fe had a negative correlation with UPRmt effector protease YME1L. None of the trace elements correlated with 4-HNE in the myocardium. The concentrations of the trace elements Mn and Zn were significantly higher in the myocardium of patients with dilated cardiomyopathy than in patients with ischemic cardiomyopathy. A higher cumulative concentration of Fe and Zn in the myocardium was associated with a younger age at which patients received heart transplantation or LVAD, potentially suggesting an acceleration of HF. A positive correlation between myocardial Cu, Mn, and Zn and the expression of UPRmt proteins and a negative correlation between myocardial Fe and YME1L expression suggest that these trace elements exerted their actions on the human heart by interacting with the UPRmt. An altered generation of oxidative stress was not an underlying mechanism of the observed changes. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 17, 9648
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25179648
URN:NBNurn:nbn:hr:105:934941
Datum objave publikacije2024-09-06
ProjektŠifra: IP-2019-04-1449
Naziv (hrvatski): Mitohondrijske podpopulacije i UPRmt u dijabetičkoj kardiomiopatiji
Naziv (engleski): Mitochondrial Subpopulations and UPRmt in Diabetic Cardiomyopathy
Kratica: SweetMitochondria
Voditelj: Filip Sedlić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/1422-0067/25/17/9648
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-20 09:29:26
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