Headaches are very common during the period of adolescence. They have negative impact on studying, their performance in curricular and extracurricular activities, relations with their peers and, they are also the reason of frequent lesson absence. According to The International Classification of Headache Disorders 3rd edition (beta version) published in 2013., headaches are divided in primary and secondary headaches. Primary headaches in adolescence are migraine and tension-type headache, and among the trigeminal autonomic cephalgias (TACs), cluster headache occurs, but extremely rarely. Migraine headache is characterized by unilateral, pulsating pain in the area of the forehead, eye and temples. It is accompanied by nausea, vomiting, photophobia and phonophobia. In tension-type headache the pain is bilateral, pressure type or constricting type and it does not increase with routine physical activity. Usually, nausea and vomiting are not present, photophobia and phonophobia can be present but not both at the same time.Cluster headache is characterized by a periodic appearance of very strong pain, usually located orbitally, supraorbitally or temporally,associated with ipsilateral autonomal symptoms and feeling of restlessness and agitation. Experts are still divided about the pathogenic mechanisms of the development of primary headaches. Diagnosis is based on anamnesis and clinical manifestation. The goal of the therapy is to classify the type of headache, explain the nature of the disease to parents and adolescent as well as improve the quality of life. In treatment of primary headaches, other than the pharmacotherapy, it is very important to change the lifestyle. Also, the role of the psychologist, relaxation trainings and biofeedback, is important. Proper treatment on time makes the disease tolerable. The goal of this review is to give an overview of primary headaches in adolescence, to outline their clinical manifestations as well as present new differential diagnostic critera (ICHD-3 2013) and treatment methods.