Cystic fibrosis is a hereditary, autosomal recessive disease that affects many organs and organic systems. The main feature of cystic fibrosis is the formation of a thick, sticky secretion in all sites where the gland has external excretion, most notably in the airways, the pancreas, the intestine, the gall bladder, the reproductive system, and the sweat glands. Disease is a progressive course and affects virtually all organs in the body, and can lead to significant shortening of life span. Today, patients experience the second and third decades, and life expectancy is determined by chronic lung disease. Today, patients experience the second and third decades, and life expectancy is determined by chronic lung disease. Thanks to the introduction of a whole series of interventions in the course of the disease, significant progress has been made in the last decades in prolonging the lifespan of patients, so that the average life expectancy for patients is 41 years, according to European and American records. Prior to the introduction of modern treatment methods, the main clinical manifestation of cystic fibrosis manifested through disorders in the digestive tract. By developing different therapeutic approaches, the problems related to the digestive tract over time have become controlled, and the site of the leading clinical problem takes over the progressive loss of lung function, deteriorating nutritional status with the drug adherence problem. Long-term systemic monitoring of patients showed high correlations in the degree of malnutrition with weight loss and pulmonary function decrease. Weight loss and malnutrition are significant lifelong predictors independent of pulmonary function. This paper presents all the complexity of the care of patients with cystic fibrosis with emphasis on the nutritional status of the patient and its effect on lung manifestations of the disease as well as their influence on anxiety, depression and adhesion in patients with CF. Disposal of a patient is not possible without a multidisciplinary team where a nurse has an extremely important role.