Supportive therapy is a treatment method whose aim is not only to prevent, but also to minimize complications and relieve side-effects of drugs used to inhibit and diminish the complications which occur due to tumorous disease. The main goal of supportive therapy is to ameliorate the quality of life. A holistic and multidisciplinary approach to the patient is necessary and good cooperation with the patient’s family is essential. The priorities of supportive treatment in hematological malignancies are the treatment of emesis, pain management,as well as treatment of cachexia and hematological complications such as anemia, neutropenia, and lytic bone lesions. One of the main purposes of supportive therapy is pain management. In order to treat the pain as well as possible, it is crucial to choose the drugs wisely and to accommodate the dosage depending on the patient characteristics. Also, it is very important to control the pain during the whole day. Prevention is the key in treating emesis. Emesis can be caused by the underlying illness or by treatment procedure. Nutritional status makes it possible to recognize patients with an increased risk of cachexia, so sufficient caloric intake should be provided to those patients. Treatment of anemia is imperative because of its negative effect on all of the systems in the human body. The most common, but also most notable, symptom is fatigue, which can additionally worsen the quality of life.