The HIV epidemic is a global health challenge and the epidemic is still growing nowadays. This disease doesn’t affect only individuals, but entire households, communities, and carry an economic burden at the level of economic development and growth of a nation. Unfortunately, most of the people that are at risk of the HIV infection or are already seropositive, live in the developing world where prevention, care, and treatment are still not in line with the severity of the problem. The HIV infection can be the source of a tremendous number of health issues related to the immunodeficiency that it confers to the persons affected. Dermatologic manifestation in HIV positive individuals, are part of the wide spectrum of illnesses that go along this retroviral infection. Virtually, all skin conditions that the general population is susceptible to develop can affect the HIV positive population with greater concern, in terms of therapeutic measures and probable complications. A variety of neoplastic, infectious, and noninfectious diseases can produce cutaneous manifestations throughout the course of HIV disease. These manifestations may occur more frequently than in persons without HIV infection and may be less responsive to usual treatment modalities. Although no cure is still available, a wide range of therapy exist to treat the various disease and complications, and improve the quality of life of HIV patients.