INTRODUCTION: Amiodarone is a drug frequently used in patients with heart failure awaiting heart transplantation. Due to its very complex pharmacokinetics some concerns about the safety of pre-transplant amiodarone use have been raised. ----- AIM: The aim of this research was to investigate the effect of amiodarone use prior to the transplantation on outcomes of transplantation, with the primary outcome of interest being 30-day mortality. ----- METHODS: This research was a retrospective review of 177 patients that underwent heart transplantation. The patients were divided into 2 groups based on the pre-transplant use of amiodarone and compared based on their perioperative characteristics and postoperative outcomes. ----- RESULTS: Statistically significant difference between the 2 groups in their preoperative characteristics was observed in the number of patients with LVAD (11/55 vs.7/121; p=0.004) and atrial fibrillation (34/55 vs. 27/119; p<0.001) and in the need for inotropic support (31/55 vs. 36/120; p<0.001). In the postoperative results statistically significant difference was observed in cardiac index (3.61 [3.2-4.0] vs. 3.9 [3.3-4.6]; p=0.034) measured in the first postoperative day. No statistically significant difference was determined regarding 30-day mortality (7/55 vs.12/122; p=0.565). ----- CONCLUSION: Pre-transplant amiodarone use is not associated with mortality.