Hepatic stellate cells or Ito cells are located in subendothelial, pericapillary space of Disse. Cellular processes, that contain microtubules and actin filaments, extend from cell body. They make contact with neighboring hepatocytes and endothelial cells of sinusoidal capillaries. Ito cells store 50 to 80 % of vitamin A in organism. That's why significant part of their cytoplasm is consisted of vitamin A in form of lipid droplets. Beside that, they have key role in the metabolism of vitamin A, they secrete cytokines and growth factors and play an important role in modulating the immune response in the liver. They are also involved in the regeneration of the liver, production of extracellular matrix components and control of the blood flow through the sinusoidal capillaries of liver lobules. These complex functions are enabled by interactions of these cells and their microenvironment through different types of receptors that are located on surface of cell membrane and in nucleus of cell. Among these receptors, especially interesting are receptors for transforming growth factor β (TGF-β) and retinoid receptors. During liver damage, Ito cells are activated with the functional and morphological change, and receive characteristics of myofibroblasts. In this form, they actively participate in the process of liver fibrosis, which ultimately leads to cirrhosis and liver failure. Since the therapeutic options for liver cirrhosis are still very limited, the aim of series of studies that are currently conducted is to find an adequate therapeutic site of action on Ito cells in order to withdraw the fibrosis.