Inflammatory bowel disease is a chronic inflammatory disorder with two seperate entities, Crohn's disease and ulcerative colitis. The etiology of disease is multifactorial, it consists of genetic predisposition, abnormalities in immune regulation and the effect of enviromental factors. The diagnosis of IBD is based on the correlation between medical history, endoscopic parameters and histopathology. The goal of today's therapy is mucosal healing, and anti-TNF monoclonal antibodies are new drugs with success in achieving this goal. The primary goal of this paper was to determine the presence of general morphological features of IBD in endoscopic colon biopsies. The specific objectives were to determine the presence of reliable morphological features that can help differentiate between two entities of IBD and to determine the interdependance of endoscopic and histological activity of the disease. For the purpose of producing this study a retrospective research of 32 patients, 21 with Crohn's disease and 11 with ulcerative colitis, was done. The most commonly found morphological parameters of IBD were basal plasmacytosis and changes in the shape and architecture of the crypts. To evaluate and compare Crohn's disease activity, CDEIS endoscopic classification and AHS histological classification of disease were used. To evaluate and compare the activity of ulcerative colitis, Mayo endoscopic classification and Nancy histological classification of disease activity were used. Regarding Crohn's disease, statistical tests found a positive correlation (r = 0,122) between two classifications and calculated p value was 0,966. A positive correlation (r = 0,574) was found in ulcerative colitis, with a p value of 0,288. The calculated results are not statistically significant but they represent the complexity of IBD and the need for further research.