Osteoarthritis (OA) is the most common articular disease of the developed world and a leading cause of chronic disability. Epidemiological studies suggest that about 15% of the world population suffers from OA. OA was for decades described as a mechanical disorder. Nowdays it is known that inflammation plays significant role in the pathogenesis of the disease. OA can occur in any synovial joint in the body. But it is the most common in weight bearing joints such as the hips, knees and the ankle. The diagnosis of OA can usually be made clinically and then comfired by radiography. The main features that suggest the diagnosis include pain, stiffness, reduced movement, swelling, crepitus. Pain is the most prominent symptom of OA and the most common reason why OA patients consult their general practitioner. Phatophysiology pain mechanisms in OA haven't been yet well understood. The pain of OA is believed to be driven by nociceptive and inflammatory mechanisms. Increasing evidence supports the hypothesis that neuropathic mechanisms may also be contributing to the pain associated with OA. Treatment goals for the OA patients include a reduction in pain, an improvement in joint mobility and to limit functional impairment. To properly manage OA, both nonpharmacological and pharmacological modalities may be used, while minority of patients will require surgery. Recognizing OA patients who have experienced pain with neuropathic features as a distinct subgroup will allow clinicians to improve the management of their symptoms.