We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157 particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces either thrombosis or bleeding/thrombocytopenia) and in a series of different injury models, acute and chronic, BPC 157 consistently advances healing after severe injuries in various tissues spontaneously unable to heal; stimulates egr-1 and naB2 genes; exhibits high safety. Hypothesis, that BPC 157 (since formed constitutively in the gastric mucosa, stable in human gastric juice, along with significance of NO-synthase and the basal formation of NO in stomach mucosa, greater than that seen in other tissues) exhibits a general, effective competing both with L-arginine analogues and L-arginine, and that this has some physiologic importance, later, practically supports its beneficial effects illustrating BPC 157 and NO-system mutual relations in gastric mucosa and mucosal protection, following alcohol lesions, in cytoprotection course, NO-generation, and blood pressure regulation; alcohol acute/chronic intoxication, and withdrawal; cardiovascular disturbances, chronic heart failure, pulmonary hypertension, and arrhythmias; disturbances after hypokalemia and hyperkalemia, and potassium-cell membrane dysfunction; and finally, in complex healing failure, proved by the fistulas healing, colocutaneous and esophagocutaneous. However, how this advantage of modulating NO-system, may be practically translated into an enhanced clinical performance remains to be determined.