Autologous breast reconstruction is becoming an integral part of the breast cancer treatment including mastectomy. Numerous researchers have recorded spontaneous recovery of sensation in the skin of reconstructed breasts, but its extent in noninnervated flaps seems to be variable and unpredictable. Breast sensation has a considerable effect on postoperative quality of life. The purpuse of our study was to subjectively and objectively examine the recovery of sensation after TRAM and DIEP free flap microvascular reconstruction. 19 patients who had their breast reconstructed in the last 5 years at Department of Plastic, Reconstructive and Cosmetic Surgery, University Hospital Center Zagreb agreed to participate. Touch sensation was measured quantitatively using Semmes-Weinstein monofilaments, cold and warm were assessed qualitatively. We focused on the recovery of sensation in the exposed skin island of the flap. The major mechanism of spontaneous reinnervation appears to be axonal regeneration of transected nerves from the recipient bed, whereas regenerative sprouting from adjacent skin margins seems to be less consistent. According to its muscle component TRAM flap has the lower capacity of sensory reinnervation by mechanism of axonal regeneration from recipient bed compared to DIEP flap. Trastuzumab immunotherapy was demonstrated to contribute to earlier and more extensive recovery of touch sensation. Among the tested sensory modalities, touch was the best recovered sensation. The highest level of touch sensation was achieved in superomedial part of the TRAM flap skin island. In inferior areas of TRAM flap skin island all sensory modalities appeared first and regenerated in the greatest number of patients. The earliest objectively measurable touch sensation was recorded 5 months after the reconstruction with TRAM and DIEP flap.