prikaz prve stranice dokumenta Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits
  Preuzmi
PDF 51.89 MB
Znanstveni rad - Izvorni znanstveni rad
Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits
Journal of Tissue Engineering and Regenerative Medicine, 14 (2020), 1; 147-159. https://doi.org/10.1002/term.2981
Vukičević, Slobodan; Grgurević, Lovorka; Erjavec, Igor; Pećin, Marko; Bordukalo‐Nikšić, Tatjana; Stoković, Nikola; Lipar, Marija; Capak, Hrvoje; Matičić, Dražen; Windhager, Reinhard; Sampath, T. Kuber; Gupta, Munish

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Vukičević, S., Grgurević, L., Erjavec, I., Pećin, M., Bordukalo‐Nikšić, T., Stoković, N. ... Gupta, M. (2020). Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits. Journal of Tissue Engineering and Regenerative Medicine, 14. (1), 147-159. doi: 10.1002/term.2981

Vukičević, Slobodan, et al. "Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits." Journal of Tissue Engineering and Regenerative Medicine, vol. 14, br. 1, 2020, str. 147-159. https://doi.org/10.1002/term.2981

Vukičević, Slobodan, Lovorka Grgurević, Igor Erjavec, Marko Pećin, Tatjana Bordukalo‐Nikšić, Nikola Stoković, Marija Lipar, et al. "Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits." Journal of Tissue Engineering and Regenerative Medicine 14, br. 1 (2020): 147-159. https://doi.org/10.1002/term.2981

Vukičević, S., et al. (2020) 'Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits', Journal of Tissue Engineering and Regenerative Medicine, 14(1), str. 147-159. doi: 10.1002/term.2981

Vukičević S, Grgurević L, Erjavec I, Pećin M, Bordukalo‐Nikšić T, Stoković N, i sur.. Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits. Journal of Tissue Engineering and Regenerative Medicine [Internet]. 01.2020. [pristupljeno 09.11.2024.];14(1):147-159. doi: 10.1002/term.2981

S. Vukičević, et al., "Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits", Journal of Tissue Engineering and Regenerative Medicine, vol. 14, br. 1, str. 147-159, Siječanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:750353. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:750353
Podaci o radu
Naslov (engleski)Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits
AutorSlobodan Vukičević
AutorLovorka Grgurević
AutorIgor Erjavec
AutorMarko Pećin
AutorTatjana Bordukalo‐Nikšić
AutorNikola Stoković
AutorMarija Lipar
AutorHrvoje Capak
AutorDražen Matičić
AutorReinhard Windhager
AutorT. Kuber Sampath
AutorMunish Gupta
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Veterinarska medicina
Temeljne i pretkliničke veterinarske znanosti
Sažetak (engleski)
In the present study, we describe autologous blood coagulum (ABC) as a physiological carrier for BMP6 to induce new bone formation. Recombinant human BMP6 (rhBMP6), dispersed within ABC and formed as an autologous bone graft substitute (ABGS), was evaluated either with or without allograft bone particles (ALLO) in rat subcutaneous implants and in a posterolateral lumbar fusion (PLF) model in rabbits. ABGS induced endochondral bone differentiation in rat subcutaneous implants. Coating ALLO by ABC significantly decreased the formation of multinucleated foreign body giant cells (FBGCs) in implants, as compared with ALLO alone. However, addition of rhBMP6 to ABC/ALLO induced a robust endochondral bone formation with little or no FBGCs in the implant. In rabbit PLF model, ABGS induced new bone formation uniformly within the implant resulting in a complete fusion when placed between two lumbar transverse processes in the posterolateral gutter with an optimum dose of 100-μg rhBMP6 per ml of ABC. ABGS containing ALLO also resulted in a fusion where the ALLO was replaced by the newly formed bone via creeping substitution. Our findings demonstrate for the first time that rhBMP6, with ABC as a carrier, induced a robust bone formation with a complete spinal fusion in a rabbit PLF model. RhBMP6 was effective at low doses with ABC serving as a physiological substratum providing a permissive environment by protecting against foreign body reaction elicited by ALLO.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Tissue Engineering and Regenerative Medicine
Brojčani podacivol. 14, br. 1, str. 147-159
p-ISSN1932-6254
e-ISSN1932-7005
DOIhttps://doi.org/10.1002/term.2981
URN:NBNurn:nbn:hr:105:750353
Datum objave publikacije2020-01
URL dokumentahttps://onlinelibrary.wiley.com/doi/abs/10.1002/term.2981
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2020-11-19 12:35:33