Lengthy and complex orthopaedic surgery changes of the hip, knee and shoulder joints, as an implantation of endoprothesis, regularly are accompanied by strong pain intensity. Inadequate pain treatment can contribute to a numerous undesirable systemic side effects in the body. Further, inadequately treated pain also indirectly influence on patient satisfaction about providing health care. The aforementioned adverse effects of acute pain may be responsible for slowing recovery as well as disabling appropriate level of physical therapy and rehabilitation, which ultimately leads to prolonged hospital stay. Therefore, the intensity of postoperative pain significantly affects on the patient's recovery. Given the above facts, achieve adequate analgesia is extremely essential factor, and to accomplish optimal analgesic effect, it is necessary to take into account individual differences in the subjective experience of the pain intensity in each patient with exposure to identical surgery or trauma. Thus, implies that the pain assessment and achieving an adequate analgesia are major challenges because, on the one hand, pain is primarily an individual feels that is specific to each patient, and the other, demands an interdisciplinary approach and the cooperation between different profiles of health care professionals with patient, and depending on the specifics of the patient, sometimes requires family inclusion and participation. Applying a multimodal analgesia with analgesics of different groups of actions, it is possible to effectively decrease pain and also a development of potential drug side effects due to the possibilities of applying smaller daily doses of painkillers by combination of pharmacological methods for pain treating. The role of nurse, as a participant of interdisciplinary team, is complex and the most prominent is in the assessment and evaluation of pain, application of pharmacological and non-pharmacological methods of pain management, in recognizing and treating potential adverse effects of analgesic therapy and in the patient´s education.