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Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
Journal of Clinical Medicine, 8 (2019), 10; 1742. https://doi.org/10.3390/jcm8101742
Jamialahmadi, Tannaz; Panahi, Yunes; Safarpour, Mohamamd Amin; Ganjali, Shiva; Chahabi, Mahdi; Reiner, Željko; Solgi, Saeed; Vahedian-azimi, Amir; Kianpour, Parisa; Banach, Maciej; Sahebkar, Amirhossein

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Jamialahmadi, T., Panahi, Y., Safarpour, M. A., Ganjali, S., Chahabi, M., Reiner, Ž. ... Sahebkar, A. (2019). Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units. Journal of Clinical Medicine, 8. (10). doi: 10.3390/jcm8101742

Jamialahmadi, Tannaz, et al. "Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units." Journal of Clinical Medicine, vol. 8, br. 10, 2019. https://doi.org/10.3390/jcm8101742

Jamialahmadi, Tannaz, Yunes Panahi, Mohamamd Amin Safarpour, Shiva Ganjali, Mahdi Chahabi, Željko Reiner, Saeed Solgi, et al. "Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units." Journal of Clinical Medicine 8, br. 10 (2019). https://doi.org/10.3390/jcm8101742

Jamialahmadi, T., et al. (2019) 'Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units', Journal of Clinical Medicine, 8(10). doi: 10.3390/jcm8101742

Jamialahmadi T, Panahi Y, Safarpour MA, Ganjali S, Chahabi M, Reiner Ž, i sur.. Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units. Journal of Clinical Medicine [Internet]. 20.10.2019. [pristupljeno 08.11.2024.];8(10). doi: 10.3390/jcm8101742

T. Jamialahmadi, et al., "Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units", Journal of Clinical Medicine, vol. 8, br. 10, Listopad 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:887726. [Citirano: 08.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:887726
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Naslov (engleski)Association of Serum PCSK9 Levels with Antibiotic Resistance and Severity of Disease in Patients with Bacterial Infections Admitted to Intensive Care Units
AutorTannaz Jamialahmadi
AutorYunes Panahi
AutorMohamamd Amin Safarpour
AutorShiva Ganjali
AutorMahdi Chahabi
AutorŽeljko Reiner
AutorSaeed Solgi
AutorAmir Vahedian-azimi
AutorParisa Kianpour
AutorMaciej Banach
AutorAmirhossein Sahebkar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Background: The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients with bacterial infections in intensive care units, the aim of this study was to investigate whether any such associations exist. ----- Methods: 100 patients (46 males, mean age 67.12 ± 1.34 years) with bacterial infections who were staying in an intensive care unit (ICU) longer than 48 h but less than 7 days and who were not receiving corticosteroids were analyzed. Their serum levels of albumin, C-reactive protein, glucose, lactate, blood urea nitrogen, prothrombin (international normalized ratio), total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, PCSK9, and procalcitonin were measured. The severity of the patients’ condition was assessed by using the Glasgow Coma Scale (GCS), the Sequential Organ Failure Assessment (SOFA), and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scales. ----- Results: Using a hierarchical regression modeling approach, no significant association was found between PCSK9 levels and either the severity of disease (APACHE II, SOFA, and GCS) indices or resistance to antibiotics. ----- Conclusion: The results suggest that there is no association between PCSK9 levels and resistance to antibiotics or the condition of patients hospitalized in intensive care units.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 8, br. 10, 1742
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm8101742
URN:NBNurn:nbn:hr:105:887726
Datum objave publikacije2019-10-20
URL dokumentahttps://www.mdpi.com/2077-0383/8/10/1742
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-02-23 10:24:47