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Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients
International Journal of Molecular Sciences, 21 (2020), 8; 3025. https://doi.org/10.3390/ijms21083025
Geissler, Klaus; Jäger, Eva; Barna, Agnes; Gurbisz, Michael; Graf, Temeida; Graf, Elmir; Nösslinger, Thomas; Pfeilstöcker, Michael; Tüchler, Heinz; Sliwa, Thamer; Keil, Felix; Geissler, Christoph; Heibl, Sonja; Thaler, Josef; Machherndl-Spandl, Sigrid; Zach, Otto; Weltermann, Ansgar; Bettelheim, Peter; Stauder, Reinhard; Zebisch, Armin; Sill, Heinz; Schwarzinger, Ilse; Schneeweiss, Bruno; Öhler, Leopold; Ulsperger, Ernst; Kušec, Rajko; Germing, Ulrich; Sperr, Wolfgang R.; Knöbl, Paul; Jäger, Ulrich; Hörmann, Gregor; Valent, Peter Više autora...

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Geissler, K., Jäger, E., Barna, A., Gurbisz, M., Graf, T., Graf, E. ... Valent, P. (2020). Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients. International Journal of Molecular Sciences, 21. (8). doi: 10.3390/ijms21083025

Geissler, Klaus, et al. "Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients." International Journal of Molecular Sciences, vol. 21, br. 8, 2020. https://doi.org/10.3390/ijms21083025

Geissler, Klaus, Eva Jäger, Agnes Barna, Michael Gurbisz, Temeida Graf, Elmir Graf, Thomas Nösslinger, et al. "Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients." International Journal of Molecular Sciences 21, br. 8 (2020). https://doi.org/10.3390/ijms21083025

Geissler, K., et al. (2020) 'Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients', International Journal of Molecular Sciences, 21(8). doi: 10.3390/ijms21083025

Geissler K, Jäger E, Barna A, Gurbisz M, Graf T, Graf E, i sur.. Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients. International Journal of Molecular Sciences [Internet]. 24.04.2020. [pristupljeno 09.11.2024.];21(8). doi: 10.3390/ijms21083025

K. Geissler, et al., "Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients", International Journal of Molecular Sciences, vol. 21, br. 8, Travanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:294681. [Citirano: 09.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:294681
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Naslov (engleski)Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia - A Retrospective Analysis in 337 Patients
AutorKlaus Geissler
AutorEva Jäger
AutorAgnes Barna
AutorMichael Gurbisz
AutorTemeida Graf
AutorElmir Graf
AutorThomas Nösslinger
AutorMichael Pfeilstöcker
AutorHeinz Tüchler
AutorThamer Sliwa
AutorFelix Keil
AutorChristoph Geissler
AutorSonja Heibl
AutorJosef Thaler
AutorSigrid Machherndl-Spandl
AutorOtto Zach
AutorAnsgar Weltermann
AutorPeter Bettelheim
AutorReinhard Stauder
AutorArmin Zebisch
AutorHeinz Sill
AutorIlse Schwarzinger
AutorBruno Schneeweiss
AutorLeopold Öhler
AutorErnst Ulsperger
AutorRajko Kušec
AutorUlrich Germing
AutorWolfgang R. Sperr
AutorPaul Knöbl
AutorUlrich Jäger
AutorGregor Hörmann
AutorPeter Valent
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Although the RAS-pathway has been implicated as an important driver in the pathogenesis of chronic myelomonocytic leukemia (CMML) a comprehensive study including molecular and functional analyses in patients with progression and transformation has not been performed. A close correlation between RASopathy gene mutations and spontaneous in vitro myeloid colony (CFU-GM) growth in CMML has been described. Molecular and/or functional analyses were performed in three cohorts of 337 CMML patients: in patients without (A, n = 236) and with (B, n = 61) progression/transformation during follow-up, and in patients already transformed at the time of sampling (C, n = 40 + 26 who were before in B). The frequencies of RAS-pathway mutations (variant allele frequency ≥ 20%) in cohorts A, B, and C were 30%, 47%, and 71% (p < 0.0001), and of high colony growth (≥20/105 peripheral blood mononuclear cells) 31%, 44%, and 80% (p < 0.0001), respectively. Increases in allele burden of RAS-pathway mutations and in numbers of spontaneously formed CFU-GM before and after transformation could be shown in individual patients. Finally, the presence of mutations in RASopathy genes as well as the presence of high colony growth prior to transformation was significantly associated with an increased risk of acute myeloid leukemia (AML) development. Together, RAS-pathway mutations in CMML correlate with an augmented autonomous expansion of neoplastic precursor cells and indicate an increased risk of AML development which may be relevant for targeted treatment strategies.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 21, br. 8, 3025
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms21083025
URN:NBNurn:nbn:hr:105:294681
Datum objave publikacije2020-04-24
URL dokumentahttps://www.mdpi.com/1422-0067/21/8/3025
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-04-13 07:56:52