Rare diseases by definition are diseases that affect less than 5 individuals per 10,000 population. Although rare, when a large number of rare diseases are taken into account, we come to the data that in Europe about 6 to 8% of the total population suffers from rare diseases. Due to their complexity, rare diseases require multidisciplinary, integrated, continuous and holistic care. Today, thanks to scientific and technological developments, medicine is advancing on a daily basis, rare diseases are being treated better, patients' life expectancy is being extended, and their quality of life is improving. The role of the nurse in caring for people with rare disease is important because it is the nurse who, as part of a multidisciplinary team, coordinates care. Nurse is in charge of educating people with rare disease and planning the interventions needed to identify the needs and difficulties that may arise during care. In Europe, there is increasing talk of the need to provide integrated care as a concept that reflects the problem of improving the patient experience and achieving efficiency in the provision of health services, all in order for care to be well coordinated and continuous. In this context, the nurse is referred to as a "case manager". This master thesis mentions for the first time "case managers for rare diseases" following the example of good practices of other countries as well as recommendations for comprehensive and holistic care of the Rare Diseases Europe. The use of "case management" in working with patients would enable great progress in care, and also led to an increase in the quality of life, which is most important for patients, their families, but also health professionals and all other participants in care.