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The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis
Molecules, 26 (2021), 8; 2344. https://doi.org/10.3390/molecules26082344
Sredoja Tišma, Vesna; Bulimbašić, Stela; Galešić Ljubanović, Danica; Galešić, Krešimir; Morović-Vergles, Jadranka; Mitrović, Joško; Uchida, Koji; Tatzber, Franz; Žarković, Neven; Jaganjac, Morana

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Sredoja Tišma, V., Bulimbašić, S., Galešić Ljubanović, D., Galešić, K., Morović Vergles, J., Mitrović, J. ... Jaganjac, M. (2021). The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules, 26. (8). doi: 10.3390/molecules26082344

Sredoja Tišma, Vesna, et al. "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis." Molecules, vol. 26, br. 8, 2021. https://doi.org/10.3390/molecules26082344

Sredoja Tišma, Vesna, Stela Bulimbašić, Danica Galešić Ljubanović, Krešimir Galešić, Jadranka Morović Vergles, Joško Mitrović, Koji Uchida, Franz Tatzber, Neven Žarković i Morana Jaganjac. "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis." Molecules 26, br. 8 (2021). https://doi.org/10.3390/molecules26082344

Sredoja Tišma, V., et al. (2021) 'The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis', Molecules, 26(8). doi: 10.3390/molecules26082344

Sredoja Tišma V, Bulimbašić S, Galešić Ljubanović D, Galešić K, Morović Vergles J, Mitrović J, i sur.. The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules [Internet]. 17.04.2021. [pristupljeno 18.12.2024.];26(8). doi: 10.3390/molecules26082344

V. Sredoja Tišma, et al., "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis", Molecules, vol. 26, br. 8, Travanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:602676. [Citirano: 18.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:602676
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Naslov (engleski)The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis
AutorVesna Sredoja Tišma
AutorStela Bulimbašić
AutorDanica Galešić Ljubanović
AutorKrešimir Galešić
AutorJadranka Morović-Vergles
AutorJoško Mitrović
AutorKoji Uchida
AutorFranz Tatzber
AutorNeven Žarković
AutorMorana Jaganjac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Small-vessel vasculitis (SVV) is the inflammation of the vessel wall that can result in hemorrhage and/or ischemia. Among the histological findings in SVV are increased infiltrating neutrophils, which, due to their oxidative burst and myeloperoxidase activity, release excessive reactive oxygen species, triggering a chain reaction of lipid peroxidation and yielding reactive aldehydes such as acrolein. The implication of oxidative stress in the pathogenesis of SVV was studied, focusing on acrolein immunohistochemistry in the affected skin vessels and systemic stress response. Samples from SVV patients and healthy subjects were collected and analyzed for total serum peroxides, total antioxidant capacity, inflammatory and immunological parameters, as well as for the presence of acrolein–protein adducts in the skin tissue specimens. The obtained data showed that systemic redox homeostasis and iron metabolism are altered in SVV patients. Possible biomarkers in the evaluation of oxidative status, disease activity and prevalence were indicated. Furthermore, a strong correlation between the accumulation of acrolein–protein adducts in the skin and the progression of the disease was revealed. Thus, the results of this study demonstrate that SVV is not only associated with systemic oxidative stress but also with tissue-specific oxidative stress that promotes acrolein formation and protein modification correlating with the severity of cutaneous vasculitis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecules
Brojčani podacivol. 26, br. 8, 2344
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules26082344
URN:NBNurn:nbn:hr:105:602676
Datum objave publikacije2021-04-17
URL dokumentahttps://www.mdpi.com/1420-3049/26/8/2344
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-11-11 09:54:02