Osteoarthritis is a chronic disease characterized by the degeneration of the articular cartilage and surrounding bones leading to progressive loss of joint function. The biggest problem for the patient is daily pain and limitation in daily activities. It primarily affects the articular cartilage, but also all other articular structures responsible for joint function. There are a number of risk factors for developing osteoarthritis, the most important being old age, obesity and trauma. The primary goals of knee osteoarthritis therapy are to alleviate painful signals originating from the joint structure of the affected joint and to improve the functions of the joint itself, but also to slow down the progression of the same diseases. During treatment, it is important to consider all possible treatment options that should be chosen the most appropriate patient, given his age, symptoms, stage of the disease, comorbidity and the patient's personal preferences. Current treatment options for osteoarthritis are pharmacological, nonpharmacological, and surgical methods. Pharmacological methods of treatment can be divided into those that are administered orally, topically or with intra-articular injections. Non-pharmacological methods include education and self-help, exercise, weight reduction in obese people, walking aids, biomechanical interventions, physical therapy, and numerous adjuvant treatment options such as acupuncture. Exercise and weight loss in obese people should be considered as the first treatment option in all patients, alone or in combination with pharmacological treatment or physical medicine treatment technique. Osteoarthritis therapy is still already based in part on a symptomatic treatment. When treating a patient, we must have an individual approaches approaches and not focus on treatment based on radiographic findings because there is often a disparity between clinical images and the symptoms of radiographic images in patients. Combinations of pharmacological and non-pharmacological treatments are most commonly used to control symptoms more effectively. Surgical methods of treatment are most often used only after pharmacological and non-pharmacological methods of treatment have proved to be insufficiently effective or when degenerative processes in the knee are significantly advanced.