prikaz prve stranice dokumenta NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms
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NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms
Journal of Clinical Medicine, 10 (2021), 19; 4621. https://doi.org/10.3390/jcm10194621
Bainrauch, Ana; Šisl, Dino; Markotić, Antonio; Ostojić, Ana; Gašparov, Slavko; Bralić Lang, Valerija; Kovačić, Nataša; Grčević, Danka; Mrzljak, Anna; Kelava, Tomislav

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Bainrauch, A., Šisl, D., Markotić, A., Ostojić, A., Gašparov, S., Bralić Lang, V. ... Kelava, T. (2021). NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms. Journal of Clinical Medicine, 10. (19). doi: 10.3390/jcm10194621

Bainrauch, Ana, et al. "NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms." Journal of Clinical Medicine, vol. 10, br. 19, 2021. https://doi.org/10.3390/jcm10194621

Bainrauch, Ana, Dino Šisl, Antonio Markotić, Ana Ostojić, Slavko Gašparov, Valerija Bralić Lang, Nataša Kovačić, Danka Grčević, Anna Mrzljak i Tomislav Kelava. "NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms." Journal of Clinical Medicine 10, br. 19 (2021). https://doi.org/10.3390/jcm10194621

Bainrauch, A., et al. (2021) 'NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms', Journal of Clinical Medicine, 10(19). doi: 10.3390/jcm10194621

Bainrauch A, Šisl D, Markotić A, Ostojić A, Gašparov S, Bralić Lang V, i sur.. NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms. Journal of Clinical Medicine [Internet]. 08.10.2021. [pristupljeno 28.12.2024.];10(19). doi: 10.3390/jcm10194621

A. Bainrauch, et al., "NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms", Journal of Clinical Medicine, vol. 10, br. 19, Listopad 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:948635. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:948635
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Naslov (engleski)NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms
AutorAna Bainrauch
AutorDino Šisl
AutorAntonio Markotić
AutorAna Ostojić
AutorSlavko Gašparov
AutorValerija Bralić Lang
AutorNataša Kovačić
AutorDanka Grčević
AutorAnna Mrzljak
AutorTomislav Kelava
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Alcoholic liver cirrhosis (ALC) is the most common indication for liver transplantation (LT) in Croatia and presents a risk factor for the development of hepatocellular carcinoma (HCC). However, genetic susceptibility has not yet been systematically studied. We aimed to investigate the contribution of the risk polymorphisms PNPLA3 rs738409, EGF rs4444903, TM6SF2 rs58542926, MTHFR rs1801133, previously identified in other populations and, additionally, the contribution of Notch-related polymorphisms (NOTCH1 rs3124591, NOTCH3 rs1043996 and rs1044116, NOTCH4 rs422951). The study included 401 patients. The ALC group consisted of 260 LT candidates, 128 of whom had histopathologically confirmed HCC, and 132 of whom were without HCC. The control group included 141 patients without liver disease. Genotyping was performed by PCR using Taqman assays. The patients’ susceptibility to ALC was significantly associated with PNPLA3 rs738409, TM6SF2 rs58542926, and NOTCH3 rs1043996 polymorphisms. These polymorphisms remained significantly associated with ALC occurrence in a logistic regression model, even after additional model adjustment for sex and age. Cirrhotic patients with the PNPLA3 GG genotype demonstrated higher activity of ALT aminotransferases than patients with CC or CG genotypes. The susceptibility to the development of HCC in ALC was significantly associated with PNPLA3 rs738409 and EGF rs4444903 polymorphisms, and logistic regression confirmed these polymorphisms as independent predictors.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 10, br. 19, 4621
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm10194621
URN:NBNurn:nbn:hr:105:948635
Datum objave publikacije2021-10-08
URL dokumentahttps://www.mdpi.com/2077-0383/10/19/4621
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-07 08:11:29