prikaz prve stranice dokumenta Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study
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Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study
Journal of Neuroimmunology, 359 (2021); 577696. https://doi.org/10.1016/j.jneuroim.2021.577696
Habek, Mario; Jakob Brecl, Gregor; Bašić Kes, Vanja; Rogić, Dunja; Barun, Barbara; Gabelić, Tereza; Emeršič, Andreja; Horvat Ledinek, Alenka; Grbić, Nevena; Lapić, Ivana; Šegulja, Dragana; Đurić, Koraljka; Adamec, Ivan; Krbot Skorić, Magdalena

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Habek, M., Jakob Brecl, G., Bašić Kes, V., Rogić, D., Barun, B., Gabelić, T. ... Krbot Skorić, M. (2021). Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study. Journal of Neuroimmunology, 359.. doi: 10.1016/j.jneuroim.2021.577696

Habek, Mario, et al. "Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study." Journal of Neuroimmunology, vol. 359, 2021. https://doi.org/10.1016/j.jneuroim.2021.577696

Habek, Mario, Gregor Jakob Brecl, Vanja Bašić Kes, Dunja Rogić, Barbara Barun, Tereza Gabelić, Andreja Emeršič, et al. "Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study." Journal of Neuroimmunology 359 (2021). https://doi.org/10.1016/j.jneuroim.2021.577696

Habek, M., et al. (2021) 'Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study', Journal of Neuroimmunology, 359. doi: 10.1016/j.jneuroim.2021.577696

Habek M, Jakob Brecl G, Bašić Kes V, Rogić D, Barun B, Gabelić T, i sur.. Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study. Journal of Neuroimmunology [Internet]. 15.10.2021. [pristupljeno 22.12.2024.];359. doi: 10.1016/j.jneuroim.2021.577696

M. Habek, et al., "Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study", Journal of Neuroimmunology, vol. 359, Listopad 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:017413. [Citirano: 22.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:017413
Podaci o radu
Naslov (engleski)Humoral immune response in convalescent COVID-19 people with multiple sclerosis treated with high-efficacy disease-modifying therapies: A multicenter, case-control study
AutorMario Habek
AutorGregor Jakob Brecl
AutorVanja Bašić Kes
AutorDunja Rogić
MBZ: 147641
AutorBarbara Barun
AutorTereza Gabelić
AutorAndreja Emeršič
AutorAlenka Horvat Ledinek
AutorNevena Grbić
AutorIvana Lapić
AutorDragana Šegulja
AutorKoraljka Đurić
AutorIvan Adamec
AutorMagdalena Krbot Skorić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Aim: To determine the influence of high-efficacy disease modifying therapy (DMT) on the development of IgG SARS-CoV-2 antibody response in COVID-19 convalescent people with multiple sclerosis (pwMS). ----- Methods: Seventy-four pwMS taking high-efficacy DMTs (specifically natalizumab, fingolimod, alemtuzumab, ocrelizumab, cladribine and ublituximab) and diagnosed with COVID-19 and 44 healthy persons (HC) were enrolled. SARS-CoV2 antibodies were tested with Elecsys® Anti-SARSCoV-2 S assay. ----- Results: pwMS taking high-efficacy DMTs had a significantly higher chance of having negative titer of SARS-CoV2 antibodies compared to healthy controls (33 negative pwMS [44.6%] compared to one negative HC [2.3%], p < 0.001). pwMS taking B-cell depleting therapy (ocrelizumab and ublituximab) had a significantly higher chance of having negative titer of SARS-CoV2 antibodies compared to pwMS on all other DMTs (29 negative pwMS on B-cell therapy [64.4%] compared to four negative pwMS on all other DMTs [13.8%], p < 0.001). Out of other DMTs, two (33.3%) pwMS taking fingolimod and two (16.7%) pwMS taking cladribine failed to develop IgG SARS-COV-2 antibodies. B-cell depleting therapy independently predicted negative titer of IgG SARS-CoV-2 antibody (Exp[B] =0.014, 95%CI 0.002-0.110, p < 0.001). ----- Conclusions: A significant proportion of convalescent COVID-19 pwMS on high-efficacy DMTs will not develop IgG SARS-CoV-2 antibodies. B-cell depleting therapies independently predict negative and low titer of IgG SARS-CoV-2 antibody.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Neuroimmunology
Brojčani podacivol. 359, 577696
p-ISSN0165-5728
e-ISSN1872-8421
DOIhttps://doi.org/10.1016/j.jneuroim.2021.577696
URN:NBNurn:nbn:hr:105:017413
Datum objave publikacije2021-10-15
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S016557282100223X
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-05-13 07:58:58