The small intestine is the longest portion of the gastrointestinal tract with a total length of 5 to 6 meters, but is resistant to tumor development. The tumors of the small intestine account for only 3-6% of all gastrointestinal tumors. Tumors are divided into benign and malignant. The group of benign tumors of the small intestine consists of adenoma, hemangioma, gastrointestinal stromal tumors and lipomas. They are usually asymptomatic and occur between the ages of 50 and 80. They can be presented by signs of obstruction, bleeding, pain and weight loss. Adenomas represent the largest group and are significant because they are precancerous lesions which are the part of adenoma-carcinoma sequence. The group of malignant tumors of the small intestine consists of adenocarcinoma, neuroendocrine tumors, lymphoma and malignant gastrointestinal tumors. Carcinoids are the most common group according to histological findings and are part of a group of neuroendocrine tumors. Malignant tumors are often accompanied by symptoms such as acute hemorrhage, weight loss and abdominal pain, but often revealed at a later stage of the disease due to the lack of specificity of symptoms. In diagnosis of the small intestine tumors, the most commonly used are double-balloon enteroscopy (DBE), video capsule endoscopy (VCE), ultrasound, magnetic resonance (MR), computed tomography (CT). As a part of endoscopy, healing is possible with polypectomy method, in the case of benign tumors. For larger masses, surgical treatment has been indicated. Surgical procedure is performed by local excision, segmental resection of the bowel or pancreaticoduodenectomy. Laparoscopic surgery is performed for smaller tumors and for those with little risk of bleeding.