prikaz prve stranice dokumenta Vitamin D in liver cancer: novel insights and future perspectives
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Vitamin D in liver cancer: novel insights and future perspectives
Croatian Medical Journal, 63 (2022), 2; 187-196. https://doi.org/10.3325/cmj.2022.63.187
Markotić, Antionio; Kelava, Tomislav; Markotić, Helena; Silovski, Hrvoje; Mrzljak, Anna

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Markotić, A., Kelava, T., Markotić, H., Silovski, H. i Mrzljak, A. (2022). Vitamin D in liver cancer: novel insights and future perspectives. Croatian Medical Journal, 63. (2), 187-196. doi: 10.3325/cmj.2022.63.187

Markotić, Antionio, et al. "Vitamin D in liver cancer: novel insights and future perspectives." Croatian Medical Journal, vol. 63, br. 2, 2022, str. 187-196. https://doi.org/10.3325/cmj.2022.63.187

Markotić, Antionio, Tomislav Kelava, Helena Markotić, Hrvoje Silovski i Anna Mrzljak. "Vitamin D in liver cancer: novel insights and future perspectives." Croatian Medical Journal 63, br. 2 (2022): 187-196. https://doi.org/10.3325/cmj.2022.63.187

Markotić, A., et al. (2022) 'Vitamin D in liver cancer: novel insights and future perspectives', Croatian Medical Journal, 63(2), str. 187-196. doi: 10.3325/cmj.2022.63.187

Markotić A, Kelava T, Markotić H, Silovski H, Mrzljak A. Vitamin D in liver cancer: novel insights and future perspectives. Croatian Medical Journal [Internet]. 30.04.2022. [pristupljeno 28.12.2024.];63(2):187-196. doi: 10.3325/cmj.2022.63.187

A. Markotić, T. Kelava, H. Markotić, H. Silovski i A. Mrzljak, "Vitamin D in liver cancer: novel insights and future perspectives", Croatian Medical Journal, vol. 63, br. 2, str. 187-196, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:159421. [Citirano: 28.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:159421
Podaci o radu
Naslov (engleski)Vitamin D in liver cancer: novel insights and future perspectives
AutorAntionio Markotić
AutorTomislav Kelava
AutorHelena Markotić
AutorHrvoje Silovski
AutorAnna Mrzljak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA KIRURGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Sažetak (engleski)
Vitamin D has been a focus of attention in liver cancer due to its direct and indirect antineoplastic effects. This review critically evaluates data from recently published basic and clinical studies investigating the role of vitamin D in liver cancer. Basic studies indicate that vitamin D plays an important role in liver cancer development by suppressing the activity of hepatic stellate cells and Kupffer cells. Furthermore, vitamin D has a direct anti-proliferative, anti-angiogenic, proapoptotic, and prodifferentiative effect on liver cancer cells. Recent investigation suggested several interesting mechanisms of these actions, such as inactivation of Notch signaling, p27 accumulation, and tyrosine-protein kinase Met/extracellular signal-regulated kinases inhibition. On the other hand, data from clinical observational studies, although promising, are still inconclusive. Unfortunately, studies on the effect of vitamin D supplementation were generally focused on short-term outcomes of chronic liver diseases (liver enzyme levels or elastographic finding); therefore, there are still no reliable data on the effect of vitamin D supplementation on liver cancer occurrence or survival.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objavePrihvaćen za objavljivanje
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 63, br. 2, str. 187-196
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2022.63.187
URN:NBNurn:nbn:hr:105:159421
Datum objave publikacije2022-04-30
URL dokumentahttp://www.cmj.hr/2022/63/2/35505652.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-05-23 06:54:04