prikaz prve stranice dokumenta Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
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Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
Digestive Diseases and Sciences, 67 (2022), 7; 3327-3332. https://doi.org/10.1007/s10620-021-07277-8
Podrug, Kristian; Trkulja, Vladimir; Zelenika, Marko; Bokun, Tomislav; Madir, Anita; Filipec Kanižaj, Tajana; O’Beirne, James; Grgurević, Ivica

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

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Podrug, K., Trkulja, V., Zelenika, M., Bokun, T., Madir, A., Filipec Kanižaj, T. ... Grgurević, I. (2022). Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography. Digestive Diseases and Sciences, 67. (7), 3327-3332. doi: 10.1007/s10620-021-07277-8

Podrug, Kristian, et al. "Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography." Digestive Diseases and Sciences, vol. 67, br. 7, 2022, str. 3327-3332. https://doi.org/10.1007/s10620-021-07277-8

Podrug, Kristian, Vladimir Trkulja, Marko Zelenika, Tomislav Bokun, Anita Madir, Tajana Filipec Kanižaj, James O’Beirne i Ivica Grgurević. "Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography." Digestive Diseases and Sciences 67, br. 7 (2022): 3327-3332. https://doi.org/10.1007/s10620-021-07277-8

Podrug, K., et al. (2022) 'Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography', Digestive Diseases and Sciences, 67(7), str. 3327-3332. doi: 10.1007/s10620-021-07277-8

Podrug K, Trkulja V, Zelenika M, Bokun T, Madir A, Filipec Kanižaj T, i sur.. Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography. Digestive Diseases and Sciences [Internet]. 07.2022. [pristupljeno 26.12.2024.];67(7):3327-3332. doi: 10.1007/s10620-021-07277-8

K. Podrug, et al., "Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography", Digestive Diseases and Sciences, vol. 67, br. 7, str. 3327-3332, Srpanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:387531. [Citirano: 26.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:387531
Podaci o radu
Naslov (engleski)Validation of the New Diagnostic Criteria for Clinically Significant Portal Hypertension by Platelets and Elastography
AutorKristian Podrug
AutorVladimir Trkulja
AutorMarko Zelenika
AutorTomislav Bokun
AutorAnita Madir
AutorTajana Filipec Kanižaj
AutorJames O’Beirne
AutorIvica Grgurević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Background and aims: We aimed to validate newly proposed noninvasive criteria for diagnosing clinically significant portal hypertension (CSPH) using liver stiffness measurements (LSM) by transient elastography (TE) and platelet count. ----- Methods: Diagnostic performance of these new criteria for CSPH (LSM ≥ 25 kPa to rule in and Plt ≥ 150 × 109/L + LSM ≤ 15 kPa to rule out CSPH) were retrospectively tested in an independent cohort of consecutive patients who underwent hepatic venous pressure gradient (HVPG) measurements and liver biopsy due to suspicion of compensated advanced chronic liver disease. Suspicion of cACLD was based on LSM ≥ 10 kPa by TE or results of liver imaging, without overt signs of CSPH. Patients with conditions known to affect results of LSM (ALT > 5 × ULN, liver congestion, extrahepatic biliary obstruction, infiltrative liver neoplasms) were excluded. ----- Results: Seventy six (76) patients were included: 78.9% males, mean age 62 years, 36.8% suffered from alcoholic, 30.3% nonalcoholic fatty liver disease, 14.5% chronic viral hepatitis, 30.3% were obese, 52.6% had HVPG ≥ 10 mmHg, 56.6% had platelet count ≥ 150 × 109/L. LSM ≥ 25 kPa had 88.9% specificity (95% CI 73.9-96.9) to rule in, whereas Plt ≥ 150 + LSM ≤ 15 kPa had 100% sensitivity (95% CI 91.1-100) to rule out CSPH. ----- Conclusion: By using these simple noninvasive criteria 49/76 (64.5%) patients could be classified correctly for the presence/absence of CSPH, thus obviating the need for HVPG measurements.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDigestive Diseases and Sciences
Brojčani podacivol. 67, br. 7, str. 3327-3332
p-ISSN0163-2116
e-ISSN1573-2568
DOIhttps://doi.org/10.1007/s10620-021-07277-8
URN:NBNurn:nbn:hr:105:387531
Datum objave publikacije2022-07
URL dokumentahttps://link.springer.com/10.1007/s10620-021-07277-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-06-28 07:03:28