prikaz prve stranice dokumenta Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
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Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
Journal of Clinical Medicine, 11 (2022), 5; 1313. https://doi.org/10.3390/jcm11051313
Mansouri, Atena; Reiner, Željko; Ruscica, Massimiliano; Tedeschi-Reiner, Eugenia; Radbakhsh, Shabnam; Bagheri Ekta, Mariam; Sahebkar, Amirhossein

Institucijski repozitorij: Dr Med - digitalni repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Citirajte ovaj rad

Mansouri, A., Reiner, Ž., Ruscica, M., Tedeschi Reiner, E., Radbakhsh, S., Bagheri Ekta, M. i Sahebkar, A. (2022). Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases. Journal of Clinical Medicine, 11. (5). doi: 10.3390/jcm11051313

Mansouri, Atena, et al. "Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases." Journal of Clinical Medicine, vol. 11, br. 5, 2022. https://doi.org/10.3390/jcm11051313

Mansouri, Atena, Željko Reiner, Massimiliano Ruscica, Eugenia Tedeschi Reiner, Shabnam Radbakhsh, Mariam Bagheri Ekta i Amirhossein Sahebkar. "Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases." Journal of Clinical Medicine 11, br. 5 (2022). https://doi.org/10.3390/jcm11051313

Mansouri, A., et al. (2022) 'Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases', Journal of Clinical Medicine, 11(5). doi: 10.3390/jcm11051313

Mansouri A, Reiner Ž, Ruscica M, Tedeschi Reiner E, Radbakhsh S, Bagheri Ekta M, i sur.. Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases. Journal of Clinical Medicine [Internet]. 27.02.2022. [pristupljeno 29.11.2024.];11(5). doi: 10.3390/jcm11051313

A. Mansouri, et al., "Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases", Journal of Clinical Medicine, vol. 11, br. 5, Veljača 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:592076. [Citirano: 29.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:592076
Podaci o radu
Naslov (engleski)Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
AutorAtena Mansouri
AutorŽeljko Reiner
AutorMassimiliano Ruscica
AutorEugenia Tedeschi-Reiner
AutorShabnam Radbakhsh
AutorMariam Bagheri Ekta
AutorAmirhossein Sahebkar
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i.e., their pleiotropic effects, might be beneficial in the prevention or treatment of many diseases. This review discusses the antioxidant effects of statins achieved by modulating the nuclear factor erythroid 2 related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway in different organs and diseases. Nrf2 and other proteins involved in the Nrf2/HO-1 signaling pathway have a crucial role in cellular responses to oxidative stress, which is a risk factor for ASCVD. Statins can significantly increase the DNA-binding activity of Nrf2 and induce the expression of its target genes, such as HO-1 and glutathione peroxidase) GPx, (thus protecting the cells against oxidative stress. Antioxidant and anti-inflammatory properties of statins, which are independent of their lipid-lowering effects, could be partly explained by the modulation of the Nrf2/HO-1 pathway.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 11, br. 5, 1313
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm11051313
URN:NBNurn:nbn:hr:105:592076
Datum objave publikacije2022-02-27
URL dokumentahttps://www.mdpi.com/2077-0383/11/5/1313
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-10-05 09:14:56